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NFL Picks: 49ers vs Cardinals Prediction, Week 5 Vegas Odds

  • Cardinals enter at 4-0, 49ers at 2-2
  • Cardinals the last undefeated team in NFL
  • 49ers have lost two straight games

The NFC West will see a second straight week of division contests take place in Week 5. After the Los Angeles Rams and Seattle Seahawks played on Thursday, the San Francisco 49ers and Arizona Cardinals will take center stage. And with the 49ers dealing with an injury at the quarterback position, the Cardinals will have a great shot at extending their perfect start to the season to five straight games.

San Francisco 49ers vs Arizona Cardinals Schedule

  • Where: State Farm Stadium, Glendale, AZ
  • When: Sunday, October 10, 4:25PM EDT
  • How to Watch: FOX

49ers vs Cardinals Vegas Odds

Game Preview

49ers Relying On Rookie QB

Last week, the San Francisco 49ers suffered their second straight loss, dropping to 2-2 on the season after losing to the Seattle Seahawks. And things are not going to get easier for the 49ers, as they face the league’s only undefeated team on the season. And making things more difficult is the fact that the 49ers are going to be starting a rookie quarterback thanks to an untimely injury.

Oct 3, 2021; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) scores a touchdown while being tackled by Seattle Seahawks defensive back Blessuan Austin (36) and cornerback Ugo Amadi (28) during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-USA TODAY Sports
Oct 3, 2021; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) scores a touchdown while being tackled by Seattle Seahawks defensive back Blessuan Austin (36) and cornerback Ugo Amadi (28) during the fourth quarter at Levi’s Stadium. Mandatory Credit: Darren Yamashita-USA TODAY Sports

Jimmy Garoppoplo is going to sit out this game for the 49ers after he suffered an injury last week against Seattle. That means that Trey Lance will be the starting quarterback this week for the Niners. And Lance will be tasked with playing in his first full game against the 4-0 Cardinals, which will be a great opportunity for Lance to prove that he can play against the best this league has to offer.

Cardinals Look For 5-0 Start

Arizona was one of the most impressive teams in the NFL last week, as they earned a statement win over the Los Angeles Rams on the road. Arizona’s offense was the story once again in that game, as Kyler Murray paced the Cardinals and set up their fourth win in as many tries. This week, the Cardinals will have to avoid falling in what has become a trap game against a backup quarterback.

Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals quarterback Kyler Murray (1) reacts during the 37-20 victory against the Los Angeles Rams at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports
Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals quarterback Kyler Murray (1) reacts during the 37-20 victory against the Los Angeles Rams at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports

So far this season, the Arizona Cardinals have a +55 point differential, which ranks second in the NFL through four weeks behind the Buffalo Bills. For the Cardinals to improve on that number, they will have to stop the run better than they have so far this year. The Cardinals allow the second-most yards per rush attempt to opponents this season, with only the Kansas City Chiefs allowing more yards per carry.

49ers vs Cardinals Prediction & Pick

Who will win tonight’s NFL game:

Even with the Cardinals struggling to stop the run so far this season, the quarterback situation of the Niners makes the Cardinals the right bet in this situation.

Kyler Murray and the Cardinals’ offense will continue to roll, while Arizona will keep getting stops against Trey Lance and a banged-up 49ers offense. Arizona will move to 5-0 and cover the point spread in the process.

Expert Pick(s):

  • Cardinals -4
Ryan has been writing about sports betting for over a decade now, residing in sunny Orlando, Florida. He played 4 years of college basketball which gave him a true understanding of how athletes think and operate. Knup has become a true student of “investing” in sports and has spent endless hours studying odds, line moves, trends, stats and teams to become a true expert in sports betting.

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