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NFL Picks: Bills vs Titans Prediction, Week 6 Vegas Odds

  • Buffalo is 3-1 in their last four games against Tennessee
  • The underdog is 6-0 against the spread
  • Tennessee leads the all-time series 29-19

The Buffalo Bills will travel to Nissan Stadium on Monday night to take on the Tennessee Titans in a Week 6 matchup. The Bills are 4-1 and are tied for the top-seed in the AFC as they are coming off a 38-20 road win over the Kansas City Chiefs.

Josh Allen went 15-of-26 for 315 yards with three touchdowns. The Titans are 3-2 and are leading a brutal AFC South as they are coming off a 37-19 road win over the Jacksonville Jaguars. Ryan Tannehill went 14-of-22 for 197 yards with a touchdown.

Buffalo Bills vs Tennessee Titans Schedule

  • Where: Nissan Stadium, Nashville, TB
  • When: Monday, October 18, 8:15pm ET
  • How to Watch: ESPN

Bills vs Titans Vegas Odds

Game Preview

Can You Diggs It?

The Buffalo Bills love to throw the football, and a big reason is the play of wide receiver Stefon Diggs. So far this season, he has 28 receptions for 374 yards (13.4 yards per catch) with a touchdown.

In his last game against the Chiefs, he had two catches on five targets for 69 yards (34.5 yards per reception). If he can be more involved in the passing game here, it will do wonders for the Bills’ offense.

Oct 10, 2021; Kansas City, Missouri, USA; Buffalo Bills offensive tackle Daryl Williams (75) and fullback Reggie Gilliam (41) react to fans during the second half against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-USA TODAY Sports
Oct 10, 2021; Kansas City, Missouri, USA; Buffalo Bills offensive tackle Daryl Williams (75) and fullback Reggie Gilliam (41) react to fans during the second half against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-USA TODAY Sports

The Buffalo Bills have been playing excellent defense as they are allowing 12.8 points per game. In their previous game against the Kansas City Chiefs, they gave up 20 points on 392 total yards of offense (272 passing, 120 rushing).

The defense did a great job limiting an incredible offense to 5.0 yards per play. Buffalo needs to improve against the run as they allowed Kansas City to run for 5.2 yards per carry. If the Bills can sure up a little defensively, they will be in a great spot.

The King and I

The Tennessee Titans love to run the ball down their opponent’s throats, and having a running back like Derrick Henry doesn’t hurt. He so far has 142 rushes (1st) for 640 yards (1st) with seven rushing touchdowns (1st) while also adding 14 catches for 125 yards through the air.

In his last game against the Jacksonville Jaguars, Henry finished with 29 carries for 130 yards (4.5 yards per run) with three rushing touchdowns. If he can carry some momentum over to this game, it’ll be hard to stop him.

Tennessee Titans safety Kevin Byard (31) grabs Jacksonville Jaguars tight end Dan Arnold (85) as he stretches for an overthrown pass with just under four minutes to play in the fourth quarter. The Jacksonville Jaguars hosted the Tennessee Titans at TIAA Bank Field in Jacksonville, Florida, October 10, 2021.  The Jaguars trailed at the half 24 to 13 and lost with a final score of 37-19. [Bob Self/Florida Times-Union]

Jki 101021 Jaguarsvstitans 5
Tennessee Titans safety Kevin Byard (31) grabs Jacksonville Jaguars tight end Dan Arnold (85) as he stretches for an overthrown pass with just under four minutes to play in the fourth quarter. The Jacksonville Jaguars hosted the Tennessee Titans at TIAA Bank Field in Jacksonville, Florida, October 10, 2021. The Jaguars trailed at the half 24 to 13 and lost with a final score of 37-19. [Bob Self/Florida Times-Union] Jki 101021 Jaguarsvstitans 5

The Tennessee Titans need some work defensively as they have given up 26 points per game. In their previous game against the Jacksonville Jaguars, they allowed 19 points on 454 yards (256 passing, 198 rushing). They did a good job defending the red zone as the Jags scored on three of five drives that ended there.

They do need to limit big plays as Jacksonville averaged 6.9 yards per play throughout the game. If Tennessee can sure up defensively, they would be a difficult team to beat.

Bills vs Titans Prediction

Who wins the Bills vs Titans game tonight:

Ryan Tannehill isn’t going to beat the Buffalo Bills himself, and all the attention defensively for the Bills will be on running back Derrick Henry. Buffalo has been incredible defensively this season, allowing less than 13 points, while Tennessee is giving up more than double that.

The Bills are fully healthy, while the Titans are dealing with some injuries. All in all, go with the Buffalo Bills -5.5 here.

Free Pick:

  • Buffalo Bills -5.5
Tyler has a true passion for sports, DFS & sports betting in particular. Combine his love for sports with his journalistic background and you have a great guy to cover the latest industry news. He also enjoys disc golf, fishing, and traveling in his free time.

1 Comment

  • Bill sobota

    82% of betters take the favorite

    Posted on 18th October 2021 at 11:10 pm
50% UP TO $1000