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NFL Picks: Cardinals vs Browns Prediction, Week 6 Vegas Odds

  • Cardinals enter at 5-0 this season
  • Cardinals coach Kliff Kingsbury to miss game
  • Nick Chubb ruled out for Cleveland

The Arizona Cardinals and Cleveland Browns have been two of the best teams in the NFL so far in the 2021 season. But their game on Sunday may be as much about who is not there than who is there. With injuries and COVID-19 throwing a wrench into the works for both sides coming into this contest, the team that is best able to roll with the punches could come out with a signature win.

Arizona Cardinals vs Cleveland Browns Schedule

  • Where: FirstEnergy Stadium, Cleveland, OH
  • When: Sunday, October 17, 4:05PM ET
  • How to Watch: FOX

Cardinals vs Browns Vegas Odds

Game Preview

Cardinals Without Coach For This Game

The big news in the NFL heading into Sunday’s Week 6 action concerned the impending absence of Cardinals head coach Kliff Kingsbury. It was announced that Kingsbury would miss this game due to COVID-19, which is meaningful for the Cardinals given that Kingsbury is their offensive play-caller. Now, the Cardinals will have to adapt on short notice as they face a formidable Cleveland team.

Oct 10, 2021; Glendale, Arizona, USA; Arizona Cardinals defensive end J.J. Watt (99) reacts with wide receiver DeAndre Hopkins (10) after Hopkins scored a fourth quarter touchdown against the San Francisco 49ers at State Farm Stadium. Mandatory Credit: Chris Coduto-USA TODAY Sports
Oct 10, 2021; Glendale, Arizona, USA; Arizona Cardinals defensive end J.J. Watt (99) reacts with wide receiver DeAndre Hopkins (10) after Hopkins scored a fourth quarter touchdown against the San Francisco 49ers at State Farm Stadium. Mandatory Credit: Chris Coduto-USA TODAY Sports

Fortunately for the Cardinals, they still have Kyler Murray available to play regardless of the status of Kingsbury and the coaching staff. Murray has led the Cardinals to the fourth-best scoring offense in the NFL through five weeks and the league’s last remaining unbeaten record. He will need to be extra special to overcome the loss of his coach along with the opponent in this contest.

Browns Look To Run The Ball

The identity for the Cleveland Browns this season is no mystery, as it is their goal to run the ball early and often to keep the chains moving. So far this year, that has worked well for them, as the Browns are averaging over five yards per carry on the ground. And this week, they will look to exploit a weak Cardinals run defense to keep the ball away from Kyler Murray and the explosive Cardinals offense.

Oct 10, 2021; Inglewood, California, USA; Cleveland Browns running back Kareem Hunt (27) celebrates his touchdown scored against the Los Angeles Chargers during the second half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports
Oct 10, 2021; Inglewood, California, USA; Cleveland Browns running back Kareem Hunt (27) celebrates his touchdown scored against the Los Angeles Chargers during the second half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports

Arizona ranks in the bottom three in the NFL in yards allowed per carry this season, making this a very favorable matchup for the running game of the Browns. Cleveland will have to deal with the loss of starting running back Nick Chubb for this contest. But Kareem Hunt is a more than viable backup option who should be able to step in and continue the Browns’ success at running the football.

NFL Picks This Week:

Who will win tonight’s NFL game:

The loss of Kliff Kingsbury only adds to the list of issues that the Arizona Cardinals are going to have against the Cleveland Browns. Unless Kingsbury was planning on suiting up at defensive tackle, he and the rest of the Cardinals are going to get gashed by the Browns’ devastating rushing attack.

Expect the Browns to put an end to the perfect start from the Cardinals and cover the spread as a favorite.

Expert Pick:

  • Browns -3
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