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NFL Picks: Colts vs 49ers Vegas Odds, Week 7 Predictions

  • The Colts are coming off a big victory against their division rival, the Texans
  • The 49ers are coming off an early season bye week
  • Both teams only have two wins this season

This week the Indianapolis Colts travel to the west coast the take on the San Francisco 49ers. Both teams have struggled so far this season, with both only totaling two wins apiece. The 49ers are looking for their first home victory this season.

Indianapolis Colts vs San Francisco 49ers Schedule

  • Where: Levi’s Stadium, Santa Clara, CA
  • When: Sunday, October 24, 8:20 PM EST
  • How to Watch: NBS

Colts vs 49ers Vegas Odds

Game Preview

The Colts Are Looking To String Together Back To Back Victories

After a 31-3 victory over the Houston Texans last week, the Colts are looking to have back-to-back wins for the first time this season. This is a pretty even matchup when you start breaking down the statistics. The Colts’ offense is averaging 23.2 points per game on 385.2 total yards. Of those 385.2 total yards, 261.7 come via the pass, and 124.2 come via the run. The Colts’ offense is led by their quarterback, Carson Wentz. Wentz has completed 124 of 193 pass attempts for 1,545 yards and nine touchdowns. The opposition has gotten to Wentz a lot this season, with him taking 14 sacks and throwing one interception.

Indianapolis Colts quarterback Carson Wentz (2) draws back to pass Sunday, Oct. 17, 2021, during a game against the Houston Texans at Lucas Oil Stadium in Indianapolis.
Indianapolis Colts quarterback Carson Wentz (2) draws back to pass Sunday, Oct. 17, 2021, during a game against the Houston Texans at Lucas Oil Stadium in Indianapolis.

The Colts defense is holding their own, only allowing 21.3 points per game on 379.8 yards per game. Those 379.8 yards are broken down to 268.8 passing yards and 111.0 rushing yards per game. The Colts have 12 total sacks on the season and are led by Al-Quadin Muhammad and Deforest Buckner, who back have two sacks each. The Colts defense has also intercepted opposing quarterbacks five times this season.

Can The 49ers Secure Their First Home Victory

The San Francisco 49ers have two victories on the season, but none of which have come in front of their home fans. They are looking to change that this week as they host the Colts. The 49ers’ offense is averaging 23.4 points per game on 377.8 total yards per game. Of those 377.8 total yards, 255.8 come via the pass, and 122 come via the run. The 49ers’ offense is led by their quarterback, Jimmy Garoppolo. Garoppolo has completed 78 of 188 pass attempts for only 925 yards and five touchdowns. Garoppolo has been sacked six times and intercepted three times as well.

Oct 3, 2021; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) sacks Seattle Seahawks quarterback Russell Wilson (3) during the first quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-USA TODAY Sports
Oct 3, 2021; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) sacks Seattle Seahawks quarterback Russell Wilson (3) during the first quarter at Levi’s Stadium. Mandatory Credit: Darren Yamashita-USA TODAY Sports

The 49ers’ defense has been giving up 23.8 points per game on 348.6 yards per game. Of those 348.6 yards per game, 235.4 come via the pass, and 113.2 come via the run. The 49er defense has 11 sacks on the season with Nick Bosa leading the way with five. The 49ers’ defense has only one interception on the season as well.

NFL Game Picks

Both teams are struggling, but I’m looking for the 49ers to come out victorious for the first time against their home crowd this season. Look for this to be a close game though, as the numbers don’t lie, and these two teams are pretty evenly matched.

49ers 28 – Colts 24

Expert Picks:

  • 49ers Win
  • Push (-4)
  • Under (44)
I’m Brian Handzel. I’m a huge baseball fan. On any given night you can catch me watching a game, whether it is MLB, MiLB, College, or local summer leagues. As my wife says, I’m obsessed with the game. I’m even a credentialed media member for the Syracuse Mets, the Triple-A affiliate of the New York Mets. When I’m not watching baseball I’m spending time with my wife and two children, and secretly trying to get them to enjoy the game as well.

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