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US Open Predictions: Men’s Semi-Finals Preview, Vegas Odds & Picks (Sep 9)

  • Just four male players remain in the hunt for a place in the US Open final
  • A new Grand Slam champion will be crowned at Flushing Meadows this year

Then there were four in the hunt for US Open Grand Slam glory. The semi-finals in the men’s draw will take place on Friday, as four must be cut to two, as the players that will compete for their maiden Grand Slam title will be determined. However, you can find our US Open predictions for the big semi-finals right here. 


US Open Men’s Semi-Final Schedule

  • When: Friday, September 9 2022
  • Where: USTA Billie Jean King National Tennis Center, New York
  • How To Watch: ESPN/ ESPN2/ ESPN3

Karen Khachanov vs Casper Ruud Vegas Odds & Pick

PlayerVegas Odds
Karen Khachanov+166
Casper Ruud-191

Casper Ruud will be looking to reach a Grand Slam final for the second time in his career. Meanwhile, Karen Khachanov will be looking to achieve that feat for the very first time. Khachanov has certainly been one of the surprise packages at the US Open this year, as he has overcome some fierce competition to reach this stage of the competition.

His biggest win came in the quarterfinals, as he overcame Wimbledon finalist Nick Kyrgios in an ill-tempered affair. The Russian won in five sets, and hit an impressive 30 aces. Khachanov won 77% of the points on his first serve, and 67% on the second serve. But, this will be another intense fixture that he will need to prepare for.

Casper Ruud has been very impressive throughout the US Open this year, and he raised his game to a new level in the previous round against Matteo Berrettini. The Norwegian was excellent in that quarterfinal clash, as he won in straight sets. Ruud won 75% of the points on his first serve, and converted five from 14 break point opportunities.

This will only be the second meeting between the two players. Ruud won the previous meeting between the two at the ATP Masters Rome on the clay. However, we make him the clear pick to win this semi-final showdown.

US Open Predictions:

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Frances Tiafoe vs Carlos Alcaraz Vegas Odds & Pick

PlayerVegas Odds
Carlos Alcaraz-182
Frances Tiafoe+162

After one of the all-time great US Open matches earlier this week, Carlos Alcaraz will need to refocus ahead of a very testing showdown with American Frances Tiafoe. Both players have excelled at the Grand Slam this season, and both have very realistic chances of making the final over the weekend.

Alcaraz has looked like a Grand Slam winner in waiting for many years, but it’s likely that he has never had a better chance. The Spanish star played out a thrilling quarterfinal against Jannick Sinner on Wednesday evening, as he came back from 2-1 down to eventually win a five set thriller. That momentum could be key coming into this semi-final.

Frances Tiafoe has the hopes of the U.S. on his shoulders. The American has been another surprise package at Flushing Meadows this year, as the 22nd seed has beaten three players seeded in the top 15, including Rafael Nadal in the round of 16. He looked extremely comfortable under the bright lights against Andrey Rublev in the quarterfinals, as he won in straight sets.

Tiafoe won the previous meeting between the two players. However, that came on the clay in Barcelona, as he won in straight sets. We are a little surprised at just how big the American is at the current prices, and he certainly offers a lot of value.

US Open Predictions:

Alex has covered huge sporting events for various websites and publications. He has attended football European Championships, Rugby League and Union World Cups, and the Paralympics. Alex is dedicated to giving the most insightful tips for VegasOdds readers and specialises in horse racing, soccer, golf and basketball.

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