MLB: 3 Best Underdog Picks Today
The intense race to secure a Wildcard spot in the MLB continues on Wednesday, September 16, 2026, as there is a busy evening of matchups across the competition. Series head-to-heads will heat up in the respective divisions, with the Reds hosting the Los Angeles Dodgers and the Athletics traveling to the Tampa Bay Rays.
However, with the busy schedule likely to be catching up to teams, there could be potential value when making MLB picks on Wednesday. You can find the standout MLB underdog picks today here.
MLB Best Bets & Top Value Picks
- Best Pick: Los Angeles Dodgers (vs. Cincinnati Reds)
- Best Value: San Francisco Giants (vs. St. Louis Cardinals)
- Team to Fade: Chicago White Sox (vs. Cleveland Guardians)
ALSO SEE: Presidents Cup Picks, Odds & Betting Preview (Sep 24-27)
Key Game Breakdown & Predictions
Chicago Cubs vs. Atlanta Braves Prediction & Odds
Date: Wednesday, September 16 | Wrigley Field, Chicago
Game Preview
The Atlanta Braves strengthened their position at the top of the National League East on Tuesday, recording a 6-3 win over the Chicago Cubs at Wrigley Field. Atlanta were underdogs in the betting for that success, and their offensive strength sparkled in Chicago.
Their power profile could once again be a key factor to consider in the second game in the series, especially considering that Wrigley Field typically punishes any mistakes in the field.
- Best Bet: Atlanta Braves (+122)
Toronto Blue Jays vs. Detroit Tigers Prediction & Odds
Date: Wednesday, September 16 | Rogers Centre, Toronto
Game Preview
The Detroit Tigers were at their dominant best in game one of their series at Rogers Centre on Tuesday, scoring a 10-1 win over the Toronto Blue Jays. Max Scherzer has been inconsistent throughout the campaign for the Blue Jays, especially in deeper matchups.
The sharpness of the Tigers’ bullpen should be respected this week, and they look like an eye-catching value selection when considering MLB underdog picks today.
- Best Bet: Detroit Tigers (+110)
Houston Astros vs. Kansas City Royals Prediction & Odds
Date: Wednesday, September 16 | Dalkin Park, Houston
Game Preview
The Houston Astros claimed a narrow game one win in their three-game series against the Kansas City Royals at Dalkin Park on Tuesday. However, the Royals could be primed to reverse that form on Wednesday. Daniel Lynch IV has been in reliable form this season, recording an ERA of 3.52. The Astros have typically struggled to produce consistent power at home, ranking third-bottom in terms of runs scored at home with 4.3. Therefore, the road win is among the appealing MLS underdog picks today.
- Best Bet: Kansas City Royals (+127)
Best MLB Underdog Picks Today
