Premier League: Arsenal vs Southampton Prediction, Odds, and Picks (Apr 21)

By · Updated 1 year ago
  • Two teams from opposite ends of the Premier League table meet on Friday.
  • This is a must-win game for Arsenal if they want to stay on top of the table.
  • Bottom-placed Southampton are in desperate need of points.

The Gunners continue their quest for their first Premier League title since 2004. They’re four points ahead of the reining champions, Manchester City, who also got one game in hand. What this means is that failure is not an option for Mikel Arteta’s boys – they need to keep on winning.

That said, beating the bottom-placed Southampton is a must for them. Oddsmakers think they’re going to do it, but stranger things have happened in the Prem. Let’s see if everything’s going to go as planned on Friday or whether we’ll witness a huge upset.

How To Watch

  • When: Friday, April 21, 2023, at 3 p.m ET
  • Where: Emirates Stadium, London, England
  • How To Watch: Peacock



Game Preview

The Gunners haven’t been too great over the last couple of weeks, but they’re still top of the table of the English Premier League. The problem is that Manchester City are breathing by their necks with just four points fewer. Plus, the Cityzens have also played one game fewer than Arsenal. And the two top EPL teams will meet next week.

READ ALSO: Premier League: Fulham vs Leeds Prediction, Odds, and Picks (Apr 22)

Before playing Manchester City in what might be the decisive game for the EPL title, Arsenal have a much easier job on the table – they’re taking on Southampton on Friday.

Everything seems to be going in their favor ahead of the Saints game. First of all, it’s played on Arsenal’s turf. Secondly, most of Arsenal’s key men are either 100% fit or getting there. Finally, the Gunners are taking on the worst team in the league. Southampton are in the very last place in the Prem, with 51 points fewer than Arsenal.


Arsenal need to take this game seriously, even though they got a much more important game coming their way in a week’s time. The good news for them is that they’ll have their fans remind them that they need to win this. At home, they’re without a single loss to Southampton ever, and we don’t think that’s going to change this weekend.


Annie Adkins
Contributor Annie is a seasoned veteran in sports betting and has been working in the industry for over 7 years. Her goal of educating others and sharing her knowledge on the topic has brought her to VegasOdds.com where she regularly contributes to our cornerstone guides and news to help readers improve their sports betting game. If you don’t find her writing, you can bet she’ll be studying sports stats!

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