NFL Week 2: San Francisco 49ers vs Los Angeles Rams Odds, and Picks (Sep 17)

By ยท Updated 8 months ago
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  • The 49ers cruised to a 30-7 win over the Steelers in week 1.
  • The Rams defeated the Seahawks 30-13 on Sunday.
  • These teams met twice last season with the 49ers winning both games.

This week 2 all-NFC West matchup has all the makings of a great game. The 49ers are hotly tipped to reach the Superbowl this season whilst the Rams are looking to bounce back from a disappointing 2022.

How To Watch

  • FOX

Game Preview

Brock Purdy and Brandon Aiyuk combined twice for touchdowns as the 49ers defeated the Steelers. Christian McCaffrey added a score and 152 yards on the ground. The 49ers have one of the most potent offenses in the NFL and their defense is first-rate. This makes them a formidable challenge for any opponent. Against the Steelers, San Francisco’s defense recorded 5 sacks and 2 interceptions. They are likely to play a huge part in this matchup against the Rams too.

With Cooper Kupp out for at least 4 weeks Rams fans were wondering who would step up in his absence. Rookie WR Puka Nacua answered the call emphatically against the Seahawks. The 22yo finished the game with 10/15 for 119 yards and left Rams fans excited for more. Kyren Williams (2 td) and Cam Akers (1 td) provided the scoring despite limited effectiveness on the ground. However, it was the receiving corps who stole the show and they will have to do the same again to be successful this week.


It is five years since the 49ers lost a regular season game to the Rams. With Cooper Kupp ruled out it is even more of an uphill battle for Los Angeles to win this one and I can’t see it happening. I expect a high-scoring game with the 49ers coming out on top.

NFL Pick

Mike Taynton
Contributor Mike is an experienced sports bettor and analyst with a long family history in the world of journalism and media. It seems inevitable that his path has led him here to VegasOdds.com where he hopes to share his passion and knowledge of NFL with others. When not studying sports Mike can usually be found playing poker or table-top games.