NFL Week 4: Los Angeles Rams vs Indianapolis Colts Odds, and Picks (Oct 1)

By ยท Updated 8 months ago
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  • The Rams lost 16-19 to the Bengals on Monday night.
  • The Colts overcame the Ravens 22-19 in O/T on Sunday.
  • These teams last met in 2021 with the Rams winning 27-24.

The 1-2 Rams take on the 2-1 Colts here in what promises to be an interesting matchup. The Rams sit 3rd in a tough NFC West division while the Colts top the AFC South.

How To Watch

  • FOX

Game Preview

The Rams are hopeful that Cooper Kupp will be fit to return by week 5, when his spell on the IR comes to an end, so until then Puka Nacua and Tutu Atwell will remain the main men on offense. Kyren Williams will provide support from the running back room and the sophomore has looked every bit the lead back since his elevation to the role. QB Matthew Stafford will have to cut back on his recent spate of interceptions for the Rams to have success this week against a solid Colts defense.

The Colts lost to the Jaguars in week 1 but since then they have looked like a side capable of springing a few surprises this season. The fitness of RB Zack Moss has played a large part in their revival and the 4th year starter picked up 122 yards on 30 carries this week, adding 23 yards and a touchdown on two receptions. It was another huge week for kicker Matt Gay, the 29-year-old went 5/5 on field goal attempts with four of those coming from over 50 yards. Anthony Richardson will attempt to clear concussion protocol this week, with Gardner Minshew continuing the QB duties if he fails to do so.


The Rams will want this to be a free-flowing, shootout kind of game but the Colts will most likely turn it into a war. Los Angeles isn’t the kind of team to win ugly so I side with Indy here in a matchup that could swing either way as the market suggests.

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Mike Taynton
Contributor Mike is an experienced sports bettor and analyst with a long family history in the world of journalism and media. It seems inevitable that his path has led him here to VegasOdds.com where he hopes to share his passion and knowledge of NFL with others. When not studying sports Mike can usually be found playing poker or table-top games.