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NFL Week 6: 49ers vs. Seahawks Preview, Odds, Lines, Predictions, Pick

By · Updated 1 month ago
  • 49ers vs. Seahawks matchup features NFL Week 6 Thursday Night Football.
  • The two NFC West division rivals both lost their previous games.
  • Christian McCaffrey is probably out for this one.

Both the Niners and the Seahawks struggle at the moment. San Francisco is 2-3 after five games, while Seattle has three wins and two losses. However, the team from the state of Washington comes into this one following back-to-back defeats.

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How to Watch:

  • Where: Lumen Field, Seattle, Washington
  • When: Thursday, October 10, 8:15 pm ET
  • How to Watch: Prime Video

49ers vs. Seahawks Odds & Lines

TeamOddsSpreadTotals
49ers-165-3.547.5
Seahawks+140+3.547.5

49ers vs. Seahawks Preview

San Francisco lost to another NFC West rival this Sunday when the Cardinals flew back to Arizona with a 24-23 win. It was a shocker at Levi’s Stadium, particularly because the Niners couldn’t score a single point in the final 12 minutes, allowing the rivals to snatch a big-time victory.

Brock Purdy was picked twice. The young QB also had one touchdown toss and 244 passing yards. Meanwhile, Jordan Mason had 89 yards on the ground with a lost fumble, while Brandon Aiyuk scored 147 receiving yards.

Seattle lost to the Giants at Lumen Field, 29-20. Their third down conversion (3-for-11) was the main reason Daniel Jones and his boys left the stadium with a W. The second one was that QB Geno Smith had 72 rushing yards, and the rest of the team had 30. That’s terrible.

DK Metcalf fumbled the ball again after a turnover against the Lions the week before. The Seahawks defense was solid, with Rayshawn Jenkins even scoring a TD, but it wasn’t there when needed the most.

49ers vs. Seahawks Head to Head

As division rivals, these teams meet often. Last year, the 49ers won both events: 31-13 in Seattle and 28-16 at home.

49ers vs. Seahawks Predictions

This one is a must for the Niners, despite them playing on the road. A break is necessary following the home loss, and this is a good chance. The Seahawks are declining, which was expected because their opening rivals weren’t that strong. Their honeymoon is over, and the 49ers will prove that.

  • Thursday Night Football Picks: 49ers -3.5
Nikola Velickovic
Contributor Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.

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