MLS Picks: Best Bets, Odds & Predictions For This Weekend (Oct 24-25)

Soccer

Credit: AI Generated

The MLS regular season is nearing its finish line, meaning the pressure on teams to pick up points in the playoff hunt steps up a gear this weekend. Crucial matches are set for across the Eastern and Western Conferences, and you can find our MLS picks for every matchup here, as well as a best moneyline pick, a standout BTTS angle, and an over/under goals selection.  

MLS Best Bets For This Weekend & Top Value Picks

• Best Pick: Nashville SC (vs. Montreal)
• Best Both Teams to Score (BTTS): LAFC vs. LA Galaxy
• Best Value Over/Under: Colorado Rapids vs. Vancouver Whitecaps (Over 2.5 Goals)

ALSO SEE: Breeders’ Cup Classic Picks, Odds, Leading Contenders, Betting Insights & Analysis

Key Fixture Breakdown & Predictions

Columbus Crew vs. Toronto FC Prediction & Odds

Kickoff: Saturday, October 24 | 2:30 PM ET | ScottsMiracle-Gro Field, OH

Match Preview

The Columbus Crew remains in the midst of the Eastern Conference playoff fight, but their attention will be divided this week due to their participation in the U.S. Open Cup Final. The Crew have been in excellent recent form in the MLS, winning back-to-back fixtures, and landing victories in four of their previous five. 

However, Toronto FC are very much the team on the rise in the East, climbing up to tenth in the standings after going three without defeat, and losing just three of their last 13. Toronto have also avoided defeat in their previous three against the Crew, indicating value in the away win on Saturday.

• Best Bet: Toronto (+365)

Colorado Rapids vs. Vancouver Whitecaps Prediction & Odds

Kickoff: Saturday, October 24 | 9:30 PM ET | Dick’s Sporting Goods Park, OH

Match Preview

An eye-catching matchup in the Western Conference this weekend will see the Vancouver Whitecaps travel to the Colorado Rapids. The Caps sit four points clear at the top of the West, and their place in the postseason has already been assured.

The Rapids still have work to do to secure their participation in the playoffs, but they currently sit three points clear in the Wild Card spot. Colorado have been hard to beat in recent fixtures, playing out draws in their previous three. Meanwhile, the Caps have won just once in their last five. Notably, the Rapids have excelled at home, avoiding defeat in nine.

• Best Bet: The Draw (+283)

LAFC vs. LA Galaxy Prediction & Odds

Kickoff: Sunday, October 25 | 9:00 PM ET | BMO Stadium, CA

Match Preview

All eyes will be on El Trafico this weekend, as Californian rivals LAFC and LA Galaxy collide at BMO Stadium on Sunday. LAFC will secure a postseason berth with a win this weekend, but it is a notable concern that they have picked up victories in just two of the last 13 rounds.

In contrast, the Galaxy have stormed into the playoff spots following an excellent run of form after avoiding defeat in five of their previous six. However, the fact that the Galaxy have won just one of their last six on the road is a worry. Interestingly, LAFC have also avoided defeat in eleven of their 13 head-to-heads against the Galaxy at BMO Stadium.

• Best Bet: LAFC (-195)

MLS Best Parlay Pick This Weekend

• Best MLS Parlay Bet: Nashville SC, LAFC, and Houston Dynamo All To Win & Over 2.5 Goals in Colorado vs. Vancouver (+897)

Best MLS Picks For All Matches This Weekend

How to Bet On MLS This Weekend

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