CONCACAF Nations League Predictions: Best Bets and Picks for Quarterfinals

Our CONCACAF Nations League predictions cover all four quarterfinals as the competition heats up during the November international break. It’s a welcome distraction for the USMNT, after a week dominated by reports linking Mauricio Pochettino with the Manchester United job.

The USA have been the dominant force since the Nations League began in 2019, winning three of the four editions so far, although Mexico are the defending champions after beating Panama in the 2025 final. Mexico now face Jamaica, Canada take on Guatemala, the USA meet Haiti, and Curacao, fresh from their first World Cup, host Panama. The winners advance to the Finals at SoFi Stadium in March and book their places at the 2027 Gold Cup.

CONCACAF Nations League Quarterfinals Schedule

Every quarterfinal is played over two legs, with the higher-ranked team hosting the second leg. All times ET.

Tie	1st leg	2nd leg
Curacao vs Panama	Thu, Nov 12, 7:30 PM	Sun, Nov 15, 6:00 PM
Guatemala vs Canada	Fri, Nov 13, 9:00 PM	Mon, Nov 16, 8:00 PM
Haiti vs USA	Sat, Nov 14, 4:30 PM	Tue, Nov 17, 7:00 PM
Jamaica vs Mexico	Sat, Nov 14, 8:00 PM	Tue, Nov 17, 9:30 PM

Curacao vs Panama Prediction and Odds

1st leg: Thursday, November 12 · 7:30 PM ET · Stadion Ergilio Hato, Willemstad
2nd leg: Sunday, November 15 · 6:00 PM ET · Estadio Rommel Fernández, Panama City

Team	ML	Spread	Total
Curacao	+269	+0.5	O 2.25
Draw	+220
Panama	-103	-0.5	U 2.25

Odds from BetOnline. Moneylines are 90 minutes only.

This is the best value on the board. Curacao haven’t lost since their first ever World Cup this summer, they’re unbeaten at home this year, and they topped their group with 10 points while scoring 12 goals, the most of any team in the league phase. Dick Advocaat’s side have won three of their last four competitive games, with Kenji Gorre scoring four times in the group stage.

Panama are heading the other way. Thomas Christiansen’s team lost both of their World Cup defeats by a single goal and haven’t won a competitive game inside 90 minutes since beating El Salvador 3-0 in November 2025. Panama have the stronger history in this matchup, unbeaten in their three meetings with Curacao, but this is a team out of form travelling to a side full of confidence. Curacao are missing Jordi Paulina, Sontje Hansen and Roshon van Eijma, but at +269 at home, they’re worth backing.

Guatemala vs Canada Prediction and Odds

1st leg: Friday, November 13 · 9:00 PM ET · Estadio Manuel Felipe Carrera (El Trébol), Guatemala City
2nd leg: Monday, November 16 · 8:00 PM ET · BMO Field, Toronto

Team	ML	Spread	Total
Guatemala	+335	+1	O 2.5
Draw	+350
Canada	-175	-1	U 2.5

Odds from BetOnline. Moneylines are 90 minutes only.

Canada have their sights set on a second Nations League final, having lost the 2023 final to the USA and finished third in 2024-25. Jesse Marsch will have been delighted with the World Cup, where Canada reached a nation-best round of 16 before losing to Morocco, but some momentum has gone since, including last month’s 1-0 defeat to the USA.

Even so, Canada remain one of the best defensive teams in CONCACAF, with clean sheets in four of their last seven games. Alphonso Davies is back in contention, and Jonathan David has been in good form for Atlético Madrid, scoring three goals in seven La Liga appearances this season.

Guatemala are unbeaten in three, a strong response after losing five straight at the start of the year, but they’ll play this first leg with part of their stadium closed. Concacaf ordered a 25% closure after incidents in their qualifier against Suriname. Canada have won five of the last seven meetings, scoring 10 goals and conceding just one, and they should have too much quality for Guatemala.

Haiti vs USA Prediction and Odds

1st leg: Saturday, November 14 · 4:30 PM ET · Nu Stadium, Miami, FL
2nd leg: Tuesday, November 17 · 7:00 PM ET · TQL Stadium, Cincinnati, OH

Team	ML	Spread	Total
Haiti	+681	+1.5	O 3
Draw	+398
USA	-330	-1.5	U 3

Odds from BetOnline. Moneylines are 90 minutes only.

The USA are back in action after a promising World Cup run to the round of 16, although much of the build-up has focused on Pochettino’s future. On the field, the form is excellent. The USA have won four straight since losing to Belgium in Seattle, scoring 12 goals in that run, including wins over Mexico and Canada last month.

Haiti have won three of their last four, but they’ve struggled against higher-ranked opposition, losing all three World Cup games this summer against Scotland, Brazil and Morocco and scoring just twice. They don’t get much home advantage either. With the security situation in Haiti still unstable, Concacaf moved their “home” leg to Miami, so the USA will effectively play both legs on home soil. Expect a controlled win in Miami before the USA turn up the heat in Cincinnati.

Jamaica vs Mexico Prediction and Odds

1st leg: Saturday, November 14 · 8:00 PM ET · National Stadium, Kingston
2nd leg: Tuesday, November 17 · 9:30 PM ET · Estadio Monterrey, Monterrey

Team	ML	Spread	Total
Jamaica	+474	+1	O 2.5
Draw	+284
Mexico	-195	-1	U 2.5

Odds from BetOnline. Moneylines are 90 minutes only.

Mexico are the defending champions, but this is far from the Mexico that beat Panama in the 2025 final. Rafael Márquez is winless in his first four games in charge, with draws against Colombia and Peru and defeats to the USA (3-0) and Chile (2-0), and Raúl Jiménez is out until around January after knee surgery.

Kingston is never an easy trip, but the quality gap is still significant, and Mexico have far more depth to call on. This is the shortest of our four prices for a reason. If you’d rather not lay -195 on a team that hasn’t won in four, Mexico on the spread at -1 gives you your stake back if they win by exactly one goal.

CONCACAF Nations League Picks and Parlays

Combining our three strongest first-leg picks gives a much bigger return than backing them one at a time:

• USA to win (-330)
• Curacao to win (+269)
• Canada to win (-175)

Parlay odds: +656. A $100 bet returns $756, which is $656 profit.

The Curacao leg is settled first, on Thursday night, so you’ll know early whether you’re still alive heading into the weekend.

CONCACAF Nations League Picks at a Glance

Game	Pick	Odds
Curacao vs Panama	Curacao	+269
Guatemala vs Canada	Canada	-175
Haiti vs USA	USA	-330
Jamaica vs Mexico	Mexico	-195

How to Bet on the CONCACAF Nations League

Four first legs in three days means plenty of betting, starting with Curacao vs Panama on Thursday night. Here’s how to get set:

1. Pick your sportsbook. We used BetOnline’s odds for these picks. BetUS and BetWhale also cover the Nations League and accept US players.
2. Create and verify your account. Use your real details and upload your ID before betting, so any winnings are paid out without delays.
3. Get your bets in before kickoff. Curacao vs Panama starts at 7:30 PM ET on Thursday, Guatemala vs Canada at 9:00 PM ET on Friday, and both Saturday games follow at 4:30 PM and 8:00 PM ET.
4. Choose your bets. Find the games under Soccer, then CONCACAF Nations League. Back our four picks individually, or add USA, Curacao and Canada to one slip for the +656 parlay.

Tip: Soccer moneylines are settled on 90 minutes plus stoppage time, so a draw loses a moneyline bet. In a tight first leg like Jamaica vs Mexico, the spread can be the safer way in.

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