MLS Predictions: Decision Day Best Bets, Odds & Picks for Saturday, Nov 7

It’s Decision Day in MLS. All 15 games kick off on Saturday, and the last playoff spots in both conferences are on the line. We’ve been through the full slate and have our best pick, our favorite both teams to score bet, the best over/under and a four-leg parlay, plus a pick for every game.

Free MLS Betting Picks for Decision Day

Here are our picks for the standout matchups on the final day of the regular season.

Inter Miami vs. Charlotte FC: Our Best Pick

Inter Miami has been one of the best teams in MLS all season, and Lionel Messi has been the reason why, with 26 goals in 30 league appearances in 2026. At home on Decision Day, with Messi leading the line, we like Miami to finish the regular season with a win. At -270 it’s a short price, which is why it’s also the anchor leg of our parlay.

FC Cincinnati vs. Nashville SC Prediction & Odds

Saturday, November 7 | 4:00 PM ET | TQL Stadium, Cincinnati, OH

Team	Moneyline	Spread	Total
FC Cincinnati	+137	-1.0 (+350)	Over 3.5 (+104)
Draw	+286
Nashville SC	+170	+1.0 (-188)	Under 3.5 (-137)

Odds from BetOnline, checked Nov 4.

Nashville is set to lift the Supporters’ Shield on Saturday, but its season will be judged on what happens in the playoffs. Cincinnati has a lot more riding on this one, because only a win guarantees a spot in the first round.

Cincinnati’s recent form has been mixed, and with so much at stake, we don’t expect them to throw caution to the wind. That’s why we like the Under 3.5 goals at -137 as our best over/under of the day. Four or more goals is a big ask in a game where one side has to be careful and the other has nothing to prove. We also like Nashville at +170 to win, because a team playing free of pressure is a dangerous opponent for a side that’s feeling it.

CF Montreal vs. Vancouver Whitecaps: Our Best BTTS Pick

Vancouver is the favorite on the road at -148, and it’s also one of our parlay legs, but we expect Montreal to find the net too. Both teams to score at -200 is our best BTTS pick on the Decision Day slate.

Real Salt Lake vs. LA Galaxy Prediction & Odds

Saturday, November 7 | 7:00 PM ET | America First Field, Sandy, UT

Team	Moneyline	Spread	Total
Real Salt Lake	-160	-1.0 (-102)	Over 3.5 (-103)
Draw	+354
LA Galaxy	+365	+1.0 (-123)	Under 3.5 (-126)

Odds from BetUS, checked Nov 4.

The last first-round spot in the West comes down to this game. The Galaxy hold it going into the final day, so Real Salt Lake needs a win to have any chance of overtaking them.

The Galaxy are unbeaten in four, but RSL has won three of its last four, and LA has been poor on the road all year, losing seven of its 16 away games. With a playoff spot riding on it, and the home crowd behind them, we like Real Salt Lake at -160.

MLS Picks Against the Spread

The spread can be a great way to find value in soccer. With a -0.5 line, your team simply needs to win. A draw or a loss means the bet loses. Here’s our best MLS pick against the spread on Decision Day.

Minnesota United -0.5 (-135) vs. San Jose Earthquakes: Minnesota has lost just once in its last six and has been excellent defensively at home, which gives it a strong platform here. San Jose has failed to win nine of its 16 road games, and we expect Minnesota to finish the regular season on a high.

MLS Parlay Picks for Decision Day

Combining legs is a fun way to boost your payout, and these four picks make a strong MLS parlay for the final day of the regular season:

1. Inter Miami to win (-270)
2. Philadelphia Union to win (-220)
3. Vancouver Whitecaps to win (-148)
4. Nashville SC to win (+170)

Parlay odds: +802 | $100 returns $902

MLS Picks for Every Game on Decision Day

MLS Match	Our Pick	Odds
CF Montreal vs. Vancouver Whitecaps	Vancouver Whitecaps	-148
Chicago Fire vs. Columbus Crew	Over 3.5 Goals	+106
D.C. United vs. New York City FC	New York City FC	+126
FC Cincinnati vs. Nashville SC	Nashville SC	+170
Inter Miami vs. Charlotte FC	Inter Miami	-270
New York Red Bulls vs. Atlanta United	New York Red Bulls	-115
Orlando City vs. New England Revolution	Over 3.5 Goals	-119
Philadelphia Union vs. Toronto FC	Philadelphia Union	-220
Austin FC vs. Portland Timbers	Portland Timbers	-147
FC Dallas vs. Colorado Rapids	FC Dallas	+108
Houston Dynamo vs. St. Louis City	Houston Dynamo	+148
Minnesota United vs. San Jose Earthquakes	Minnesota United	-135
Real Salt Lake vs. LA Galaxy	Real Salt Lake	-160
San Diego FC vs. Sporting KC	San Diego FC	-220
Seattle Sounders vs. LAFC	LAFC	+265

How to Bet on MLS This Week

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