NFL Week 1: 49ers vs. Rams Preview, Odds, Predictions (Sep 10)

By · Updated 20 minutes ago
  • Rams vs. 49ers odds favor the Rams by 3.5 points.
  • The 49ers and Rams open their 2026 NFL regular season at the MCG Stadium in Melbourne, Australia.
  • Myles Garrett will make his debut for the Rams.

The NFC West showdown in Australia sounds fun. We can’t wait to see Myles Garrett making his first reps in the Rams jersey.

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How to Watch

  • When: Thursday, September 10, 2026, 8:35 PM ET
  • Where: Melbourne Cricket Ground (MCG), Melbourne, Australia
  • How to Watch: Netflix

49ers vs. Rams Odds

TeamMoneylineSpreadTotals
49ers+165+3.548.5
Rams-200-3.548.5

Game Preview

Brock Purdy will again orchestrate an explosive 49ers offense anchored by running back Christian McCaffrey, tight end George Kittle, and one newcomer. Veteran WR Mike Evans came from sunny Florida to an even sunnier California in search of another Super Bowl ring.

The 49ers brought one more offensive threat, WR Christian Kirk, who signed a one-year deal and will be of huge use for Purdy. As for the defense, we can’t say that it might look better, as Nick Bosa and Fred Warner still lead the way. After Bosa’s injury lin 2025r, the defense was one of the worst in the league – 31st in sacks, 30th in picks, 32nd in defensive success rate.

Now, the Rams defense is stacked with quality. One of the best defenders ever came from the Browns, Myles Garrett. Another Hall of Famer to be, Aaron Donald, is unretired, and overall, the LAR kept the previous defensive core in one place. So their defense is horrifying for the rivals.

On the other hand, Matt Stafford is back. The reigning NFL MVP, who had 46 touchdown passes last year, will have Puka Nacua back and Davante Adams. Therefore, one of the best offenses last season should keep pounding at the same pace.

49ers vs. Rams Head-to-Head

San Francisco holds a 79–72–3 advantage in the all-time series. However, the Rams won 4 of the last 5 matchups. In the 2025 season, SF was better in LA, 26-23 OT, but the Rams avenged it in the following meeting at Levi’s Stadium, 42-26.

49ers vs. Rams Predictions

We are thinking like this. The 49ers defense is fragile, yet their attack is solid. On the other hand, we don’t know whether their offensive coordinator has a solution for Garrett in the first meeting. The reigning NFL DPOY is a massive difference-maker, and the reason we bet on the Rams to win here.

Nikola Velickovic
Contributor Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.