Best MLS Bets & Parlay Picks For This Weekend (Sep 4-5)
The action in the MLS continues this weekend, as important matchups in the context of playoff places in the Eastern and Western Conferences are staged across North America. Inter Miami will be aiming to close the gap at the top of the East standings when they host Atlanta United, while the Vancouver Whitecaps will have their sights set on a third straight win in the West when they host St. Louis City. You can find our best MLS picks for the weekend, as well as a value MLS parlay selection here.
MLS Parlay Picks
MLS Best Bets For This Weekend
Inter Miami to Win vs. Atlanta United
A logical starting point this weekend comes from Nu Stadium, as Inter Miami aim to follow up on their 7-1 demolition of CF Montreal last weekend. Inter were dominant last time out, with Lionel Messi scoring four times in a stunning home win. Their chances of building on that win to strengthen their position in the Eastern Conference standings are enhanced based on the fact that Atlanta have won just twice in their eleven matches on the road in 2026. Inter have also won six of their previous ten home matches against United.
FC Cincinnati to Win vs. D.C. United
FC Cincinnati’s unbeaten run was ended last weekend, as they were thumped 4-0 by Nashville in Tennessee. However, they will be expected to get back on track in front of their own fans at TQL Stadium. Cincinnati have avoided defeat in their last five at home, winning four times over that period, and scoring an impressive 17 goals. D.C. United have been poor in their away fixtures in 2026, failing to win in nine of their eleven and scoring just 1.18 goals per game. A home win is a logical inclusion when making MLS Parlay picks.
ALSO SEE: Premier League 2026/27: Our Experts Make Their Winner, Relegation, and Top Scorer Picks
Austin FC to Win vs. San Jose Earthquakes
Austin FC have been in reliable form since returning to action after the World Cup, and their Leagues Cup performances have now carried over to the MLS after winning two of their previous three, and avoiding defeat in all fixtures over that period. Austin’s recent 2-1 win over the Portland Timbers will give them confidence, while San Jose brings low confidence into this round after failing to win in their previous seven. Over that period, the Earthquakes have also failed to score more than once in their last five.
Columbus Crew to Win vs. Colorado Rapids
A slightly risky inclusion that could provide value when making MLS Parlay picks this weekend is the Columbus Crew. The Crew have suffered defeats in each of their last four MLS fixtures, but they should be capable of getting back on track on home turf this weekend. Columbus have avoided defeat in six of their eleven at home this season, and they have shown defensive strength with clean sheets in 27% of their fixtures. The Rapids will be vulnerable on the road after losing each of their last two on their travels without scoring.
LA Galaxy to Win vs. New England Revolution
The LA Galaxy round off our MLS Parlay picks for this weekend, as they bid to bounce back from a 3-1 road loss against San Diego. The Galaxy have avoided defeat in three of their last four, and they have kept clean sheets in their previous two at home. This weekend’s hosts have a strong head-to-head home record against the Revolution, avoiding defeat in 12 of the last 18 at Health Dignity Park. The Galaxy have also won four of the previous five overall head-to-heads.
MLS Parlay Picks
MLS Picks For This Weekend
| MLS Matchup | Pick |
|---|---|
| NYCFC vs. Nashville | Nashville |
| Toronto vs. Chicago Fire | Chicago Fire |
| Orlando City vs. San Diego | Orlando City |
| Philadelphia vs. Montreal | The Draw |
| Charlotte vs. Houston Dynamo | Houston Dynamo |
| Seattle Sounders vs. NY Red Bulls | Seattle Sounders |
| FC Dallas vs. Sporting KC | Sporting KC |
| Real Salt Lake vs. LAFC | The Draw |
| Portland Timbers vs. Minnesota | Minnesota |
| Vancouver vs. St. Louis | Vancouver |
