MLS Predictions: Wild Card Round Picks and Best Bets (Nov 19)

The regular season is in the books, the seedings are locked, and the MLS Cup Playoffs are finally here. Before the top seeds get going in Round One, two Wild Card games on Thursday night decide the last two places in the bracket, and both carry a little extra danger for bettors. One loss and you’re out, and a draw after 90 minutes goes straight to penalties.

Inter Miami start their bid to become the first back-to-back champions since LA Galaxy in 2011 and 2012, but first it’s Orlando City vs FC Cincinnati in the East and Seattle vs Real Salt Lake in the West. Here are our MLS predictions, the latest odds and our best bets for the Wild Card round.

Orlando City vs FC Cincinnati Prediction and Odds

Thursday, November 19 | 7:30 PM ET | Inter&Co Stadium, Orlando, FL | Apple TV

Team	Moneyline	Spread	Total
Orlando City	+147	PK	Over 4
Draw	+305
FC Cincinnati	+151	PK	Under 4

Odds from BetOnline, checked Nov 11.

The winner here gets a Round One series with Supporters’ Shield winners Nashville SC, with Game 1 in Nashville on Sunday, November 22. Orlando have made the playoffs in each of the last five seasons, and expectations shot up after the summer arrival of World Cup winner Antoine Griezmann. The Frenchman has delivered, with 15 goals in 22 appearances in all competitions.

Orlando’s form is solid but not spectacular. They’ve lost just once in seven since the start of October, but they’ve only won two of their last five. FC Cincinnati saved their season late, winning three of their final four, with the only loss coming on Decision Day against Nashville.

The head-to-head is basically a wash, with six Orlando wins to Cincinnati’s five across the last 16 meetings. Where this tilts is venue. Orlando have won 10 of their 17 at Inter&Co in 2026, while Cincinnati have failed to win 14 of their 17 on the road. A team that bad away from home shouldn’t be priced almost level with the home side, so Orlando at +147 is the value play.

Pick: Orlando City (+147)

Seattle Sounders vs Real Salt Lake Prediction and Odds

Thursday, November 19 | 10:00 PM ET | Lumen Field, Seattle, WA | Apple TV

Team	Moneyline	Spread	Total
Seattle Sounders	-103	-0.5	Over 3
Draw	+284
Real Salt Lake	+253	+0.5	Under 3

Odds from BetOnline, checked Nov 11.

The late game on Thursday decides who gets top seed Vancouver Whitecaps in Round One. It’s been a rollercoaster season in Seattle: an eight-game losing run between May and August, then a nine-game unbeaten streak from late August into October. The finish was flat, with three losses in their last six and only a Decision Day win over LAFC to show for that stretch.

Real Salt Lake had the same up-and-down shape. They went 12 games without a win from late July to late September, then won five of their final eight. The problem is the road. RSL lost six of their last eight away from home, and now they have to win at Lumen Field.

Despite Seattle’s poor finish, the market still makes them clear favorites, and history backs that up: the Sounders have won 17 of their last 24 home meetings with Real Salt Lake. At close to even money, the home win is the standout angle.

Pick: Seattle Sounders (-103)

MLS Parlay Picks for the Wild Card Round

Want more from Thursday night? Put both home sides together:

• Orlando City to win (+147)
• Seattle Sounders to win (-103)

Parlay odds: +387 | A $100 bet returns $487

These are 90-minute moneylines, so a draw in either game, even one that ends with a shootout win, loses the parlay.

MLS Cup Odds and Futures

Thinking bigger than one night? Nashville SC lead the MLS Cup odds at +400, with Inter Miami and Vancouver at +450. Prices on Round One winners will move fast once the Wild Card is done, so if you like a team to go deep, now is the time to lock in a number. See our full MLS Cup odds page for every team’s price and our picks to win it all.

How to Bet on MLS This Week

Both Wild Card games are on Thursday, November 19, with Orlando vs Cincinnati at 7:30 PM ET and Seattle vs Real Salt Lake at 10:00 PM ET, so you can back the early game and go again before the late one, all streaming on Apple TV. Just remember how Wild Card games work: a draw after 90 minutes means penalties, and your moneyline bet is settled on the 90-minute result. If you only care about who goes through, look for a “to advance” or “to qualify” market, which counts extra time and penalties.

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