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Bills vs. Jets Prediction: Odds, Spread and Best Bets for Week 10

  • Nikola Velickovic
  • Nov 10, 2026 at 2:11 PM EST

ATS pick: Bills -8

Over/Under pick: Under 51

Claim Up to $250 Free Bet at BetOnline

The AFC East clash between the Bills and the Jets is one of the more intriguing Bills vs. Jets matchups in years, for all the wrong reasons if you’re a Jets fan. The Bills (7-1) are clear favorites, coming off a dominant Monday Night Football win in Minnesota.

The Jets (2-7) look bad, sometimes worse than they really are. They have some talent, but they’re badly undisciplined, and it keeps costing them. Against Buffalo, the Jets are big underdogs at +340, though they have nothing to lose and the home crowd behind them.

For our pick on every game this week, check out our NFL Week 10 picks against the spread.

Sunday, November 15 | 1:00 PM ET | MetLife Stadium, East Rutherford, NJ | CBS

Bills vs. Jets Odds

TeamSpreadMLTotal
Bills-8-435O 51
Jets+8+340U 51

Odds from BetOnline as of Tuesday, November 10. For the latest lines on every game, see our NFL odds page.

The Bills’ -435 moneyline gives them an implied win probability of around 81%. The Jets are +340, the spread is 8 and the total is 51. That total has climbed from an opening 46.5, so the market expects points.

Bills Odds and Form: Allen Rolling Towards Another MVP

The Bills are playing impressive football. They beat the Vikings 23-6 in Minneapolis on Monday Night Football, holding one of the league’s best teams to two field goals. Josh Allen had a quiet night by his standards, going 21 of 31 for 234 yards with a touchdown and an interception, but he still controlled the game.

Allen is right at the top of the NFL MVP odds. He’s already thrown for more than 2,000 yards, with 12 touchdown passes and 9 rushing touchdowns, and he’s on pace for one of the best seasons of his career.

He and James Cook lead the NFL’s No. 1 offense, which averages 32 points per game. The defense is more average, strong against the run but leaky against the pass. If Buffalo can tighten up its secondary, it’s hard to see anyone stopping them.

Jets Odds and Form: Poor Results and Indiscipline

Looking at the Jets’ recent results, it’s tempting to write this team off. They’ve lost four straight, allowing 127 points in that stretch, to fall to 2-7. Not everything is bad at MetLife, though. Linebacker David Bailey is one of the favorites for Defensive Rookie of the Year, and there’s real potential on defense. The problem is discipline.

Heading into Week 10, the Jets have the second-most penalties in the NFL, with 73 for 572 yards. Only the Packers have more, but Green Bay has an offense that can cover for it, and the Jets don’t.

Geno Smith has thrown for 2,078 yards with 12 touchdowns and only 3 interceptions, which is solid. But the Jets are last in the NFL in red-zone touchdown rate, scoring touchdowns on just 42% of their trips inside the 20.

Bills vs. Jets Predictions: Best Bets

Against the Spread Pick: Bills -8

The Bills are No. 1 in most power rankings right now, and we couldn’t agree more. The Jets are an undisciplined team well below .500 that struggles to finish drives and has an inconsistent defense. Buffalo has the MVP favorite and one of the league’s best running backs, while the Jets commit more than eight penalties a game. That’s a big gap in quality, and it should show on the scoreboard.

Over/Under Pick: Under 51

The Bills held the Vikings to 6 points and the Ravens to 10 the week before. Their defense isn’t elite, but it’s shown it can smother inconsistent offenses like the Jets’. And if Buffalo gets out to a double-digit lead, expect them to lean on Cook and run the clock. In that game script, 51 points is a lot.

  • Josh Allen. The MVP favorite is playing at an elite level.
  • The NFL’s No. 1 offense. At 32 points per game, Buffalo has the league’s best-scoring offense.
  • Jets indiscipline. 73 penalties for 572 yards, the second-most in the league.

How to Bet on Bills vs. Jets

Want to back our Bills vs. Jets picks? The sportsbooks below accept US players and post odds on every NFL game as soon as the lines are released, with spreads, moneylines, and totals for this AFC East rivalry game available all week.

  1. Pick a sportsbook from the table below and create your account.
  2. Make your first deposit and claim the welcome offer.
  3. Find the game under NFL in the sportsbook menu, listed with the Sunday 1 PM ET kickoffs.
  4. Choose your bet, whether that’s the Bills -8, the Under, or both; enter your stake and confirm.

The spread has already dropped from 8.5 to 8. At -8, a Bills win by exactly eight points is a push rather than a loss, so if you like Buffalo, this is a better number than the one it opened at.

Sportsbook ratings

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