Jacksonville Jaguars vs Indianapolis Colts Odds, and Picks (Sep 10)

By · Updated 7 months ago
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  • Jacksonville went 9-8 last season, and won a weak AFC South division.
  • The Colts had a very rough showing, posting a final record of 4-12-1.
  • These two teams last met on October 16, in a game the Colts won 34-27.

The NFL season kicks off next week. Let’s preview the upcoming Jaguars vs Colts AFC South clash. Jacksonville is heavily favored to repeat as division champions, while the Colts start a new era at QB.

How to Watch

  • FOX


The Jaguars took a big step forward last year in QB Trevor Lawrence’s 2nd season. With the Urban Meyer days behind them, Jacksonville and Lawrence will now benefit from being in the same system for two years in a row. Between their continued improvement, and a very weak AFC South division, the Jaguars may be one of the safest preseason bets to make the playoffs. They need to avoid a surprise upset here.

KANSAS CITY, MO - JANUARY 21: Jacksonville Jaguars quarterback Trevor Lawrence 16 looks to pass in the first quarter of an AFC divisional playoff game between the Jacksonville Jaguars and Kansas City Chiefs on January 21, 2023 at GEHA Field at Arrowhead Stadium in Kansas City, MO. Photo by Scott Winters/Icon Sportswire NFL, American Football Herren, USA JAN 21 AFC Divisional Playoffs - Jaguars at Chiefs Icon2301210195

Indianapolis named rookie QB Anthony Richardson as their starter, officially starting a new era. After fielding Jacoby Brissett, Brian Hoyer, Phillip Rivers, Carson Wentz, Matt Ryan, Nick Foles, and Sam Ehlinger at the QB spot in the 4 seasons since Andrew Luck last took the field, the Colts should finally have their QB of the future. It make take time for Richardson to acclimate to the NFL level, but Indy’s future is bright.


With an inexperienced Richardson getting his first NFL start, and RB Jonathan Taylor on the PUP list, it’s hard to imagine the Colts producing much on offense in this game. That being said, they did score 34 points in their last matchup against Jacksonville, so it can’t be totally ruled out. Unless Richardson comes out playing like a superstar in Week 1, the Jaguars should get a pretty easy road victory to start their year.

NFL Picks:

  • Jaguars 27, Colts 16 ()
Keith McCarthy
Contributor Keith McCarthy is an experienced sports analyst with a passion for predicting the outcomes of games spanning across sports such as football, basketball, baseball, and hockey, with a special expertise in college sports.