NFL Odds, Predictions: Jaguars vs. Broncos Week 2 Preview & Picks (Sep 20)

By · Updated 3 minutes ago
  • Jaguars vs. Broncos odds favor Denver by 2.5 points.
  • Broncos allowed 220 rushing yards against the Chiefs.
  • Trevor Lawrence threw for 4 TD passes.

This is yet another high-stakes matchup early into the season. The Jags and the Broncos won their respective AFC divisions last year, and the result of this matchup could have massive implications for the playoff picture.

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How to Watch

  • When: Sunday, September 20, 2026, 4:05 PM ET
  • Where: Empower Field at Mile High, Denver, Colorado
  • How to Watch: CBS

Jaguars vs. Broncos Odds

TeamMoneylineSpreadTotals
Jaguars+115+2.544.5
Broncos-135-2.544.5

Game Preview

Quarterback Trevor Lawrence had his day against the sorry Browns. Jags’ leader recorded 245 passing yards, 18/23, connecting his receivers with the end zone 4 times. On all 4 occasions, it was a different player.

The Broncos have a weak O-line, but still, we need to mention the 5 sacks the Jags posted. Trevon Walker and Josh Hines-Allen both had 1.5, with the latter adding 2 QB hits.

Broncos were blown into pieces on Monday Night Football against the Chiefs. Mahomes threw for 310 yards and 3 TDs, and Kansas City rolled over Denver in every aspect of play. Sean Payton’s boys allowed 220 rushing yards, something we haven’t seen for a long time.

Meanwhile, the Broncos had only 61 yards on the ground, while Bo Nix threw for 131 yards, for one TD and one pick. He would fumble the ball three times, once losing possession.

Jaguars vs. Broncos Predictions

Lawrence and the boys know how to win here, because they did that last year. Now, we didn’t like how the Broncos’ offense looked against the Chiefs, and even though Denver has a home-field edge, we will pick Jacksonville to defend the spread.

Nikola Velickovic
Contributor Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.

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