NFL Odds, Predictions: Titans vs. Colts Week 6 Preview & Picks (Oct 18)
- Titans vs. Colts odds favor Indianapolis as a heavy favorite, -325.
- Colts are the 5th-worst scoring defense, allowing 27.6 points.
- Titans are winless after 5 rounds.
Another AFC South clash is on the way. This time the sorry Titans are searching for their first win of the year in Indianapolis, where they meet the Colts.
Here is the full NFL Week 6 odds.
How to Watch
- When: Sunday, October 18, 2026, 1:00 PM ET (12:00 PM CT)
- Where: Lucas Oil Stadium, Indianapolis, Indiana
- How to Watch: CBS
Titans vs. Colts Odds
Game Preview
There are no improvements in the Titans’ game. And let’s be honest here, Cam Ward is already starting to look like a big bust. Houston demolished Tennessee 26-3 in Week 5, with Ward posting 170 passing yards, no TD passes, and one interception.
Titans are ranked bottom in several offensive categories, like points per game and total yards per game, and really look terrible. We are pretty sure management won’t put up with this for long.
Colts lost to the Steelers in Pittsburgh, where once again their poor defense emerged. Pittsburgh stuffed 34 points, with the Colts making Aaron Rodgers look ten years younger.
Indianapolis team allows 27.6 points per game and 384.2 yards from the scrimmage. Both of these stats are among the 5 worst in the NFL. With Jonathan Taylor not playing like before, it’s completely normal to see them below .500.
Titans vs. Colts Predictions
This is an excellent chance for the Colts to regain some of their lost morale and post an easy win. Titans are way too bad to challenge Daniel Jones and the boys on the road.
Free NFL pick: Colts -7
