NFL Week 5 Predictions: Best Bets, Odds & Upset Pick

NFL

The 2026 NFL regular season enters Week 5 with a 15-game schedule as Carolina and Kansas City enter bye weeks. NFL odds are ready, the picks as well, so let’s roll.

Thursday Night Football kicks off in Arlington, with the Dallas Cowboys hosting the Tampa Bay Buccaneers at AT&T Stadium. The guests are without Baker Mayfield, while the hosts want to exploit their high-octane offense for a win.

Sunday morning features another international show at London’s Tottenham Stadium, with the Philadelphia Eagles formally “hosting” the Jacksonville Jaguars. Later that day, we have the longest-standing rivalry in pro football, as the Packers host the Bears.

Sunday Night Football features the Baltimore Ravens and the Atlanta Falcons, while Monday night brings two powerhouses, the Buffalo Bills and the LA Rams.

Below is our complete breakdown of top betting angles, value picks, key fixture previews, and the full schedule for NFL Week 5.

Week 5 Best Bets & Top Value Angles

• Best Moneyline: Buccaneers vs. Cowboys -550
• Top Spread Pick: Cowboys -10
• Top Value Over/Under: Browns vs. Jets 40.5 points

Key Fixture Breakdown & Predictions

Tampa Bay Buccaneers vs. Dallas Cowboys Prediction & Odds

Kickoff: Thursday, October 8 | 8:15 PM ET / 02:15 CET (Fri) | AT&T Stadium, Arlington, TX

Match Preview

Thursday Night Football features an explosive non-conference clash under the lights of the AT&T Stadium. Dallas enters off a huge 34–30 road win over Houston in Week 4, where the offense posted over 420 total yards. Tampa Bay is 0-4 and without Baker Mayfield, and let’s say that the boys from Florida are in big trouble. The pressure is high, and for now, they look like a team without a solution. Dallas is going to roll over them.

• Best Bet: Cowboys -10

San Francisco 49ers vs. Seattle Seahawks Prediction & Odds

Kickoff: Sunday, October 11 | 4:25 PM ET / 22:25 CET | Lumen Field, Seattle, WA

Match Preview

An intense NFC West rivalry takes center stage on Sunday at Lumen Field. San Francisco travels north after a hard-fought 24–14 Week 4 win over Denver. Seattle is 3–1 following a 30–23 win against the Chargers, where they played solid football. Why do we think that the Niners have a chance to defend the spread here? They look more consistent on both sides of the ball, especially on defense, where they look very strong and rough, kinda like the Seahawks last year.

• Best Bet: 49ers +2.5

Buffalo Bills vs. Los Angeles Rams Prediction & Odds

Kickoff: Monday, October 12 | 8:15 PM ET / 02:15 CET (Tue) | SoFi Stadium, Inglewood, CA

Match Preview

On one side, we have 2024 NFL MVP Josh Allen, and on the other, 2025 Matt Stafford. Both sides are extremely gifted offensively, with playmakers at every position. Defensively, they are good too, but not nearly as good as they are on offense. So we don’t want to speak too much here, but bet on OVER.

• Best Bet: Over 54.5 points

NFL Week 5 Upset Pick

Minnesota Vikings vs. New Orleans Saints Predictions & Odds

Kickoff: Sunday, October 11 | 1 PM ET / 7 CET | Caesars Superdome, New Orleans, LA

Match Preview

When the lines and odds were released, the Vikings were favorite according to the bookies. Slight favorites. For us, they weren’t. Minnesota is 4-0, though they have massive offensive flaws. And if Justin Jefferson isn’t 100% fit, Wes Phillips’ crew will have plenty of glitches. Meanwhile, the Saints will go all in right away, as they have to push hard and erase their Week 4 loss to the Falcons. New Orleans can break any defense, even the best, while the Vikes haven’t been great on offense in their last two games. Remember they beat the Fins 15-10, yet without a touchdown.

• Best Upset Bet: Saints

Complete NFL Week 5 Schedule & Odds Table