NFL Preseason: 49ers vs. Raiders Preview, Odds, Picks (Aug 16)

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NFL Preseason Week 2: 49ers vs. Raiders Preview, Odds, Picks (Aug 16)

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49ers vs. Raiders preseason week 2 Preview, Odds, Prediction for the game set at the Allegiant Stadium on August 16.

https://commons.wikimedia.org/wiki/File:2021_Vegas_Kickoff_Classic_at_Allegiant_Stadium_%2820210906151748%29.jpg

49ers vs. Raiders preseason game will be aired on NFL Net, Fox 5 Vegas, and KPIX.
The Las Vegas Raiders are 4.5-point favorites in this game.
The over/under line is set at 40.5 points.

San Francisco lost to the Broncos last week. It was a hard kick in the teeth for Shanahan’s boys, who now visit Pete Carroll and the Raiders.

If you are interested in more NFL odds and predictions, follow this link.

How to Watch

When: Saturday, August 16, 4 pm ET
Where: Allegiant Stadium, Las Vegas, Nevada
How to Watch: NFL Net, Fox 5 Vegas, KPIX

49ers vs. Raiders Odds

Team	Moneyline	Spread	Totals
49ers	+190	+4.5	38.5
Raiders	-225	-4.5	38.5

Game Preview

A 30-9 loss to the Broncos at Levi’s Stadium was a disappointment, even though it’s a preseason opener. Especially because the 49ers had a 9-0 lead at the end of the opening quarter. Afterward the Niners collapsed, allowing Denver to post 20 straight points.

San Francisco’s quarterbacks, Mac Jones, Carter Bradley, and Tanner Mordecai, didn’t throw for a single touchdown, but all of them were intercepted once. In total, these guys combined for 107 passing yards.

Delivery intercepted 😮‍💨#RaiderNation pic.twitter.com/sYngRziMZh
— Las Vegas Raiders (@Raiders) August 12, 2025

Pete Carroll debuted for the Raiders against the Seahawks at Lumen Field. There’s some beauty in this. Seattle managed to get away unbeaten, with the game ending in a 23-23 tie.

Aidan O’Connell threw for 205 yards for a touchdown and two picks. His top target was Shedrick Jackson, who had 4 receptions for 76 yards and a touchdown. There weren’t too many starters involved, and we only expect to see the Raiders’ top players as the preseason goes by.

49ers vs. Raiders Head to Head

There have been 15 matches between these franchises, and the current record stands at 8-7 in favor of the 49ers. San Francisco won 4 of the previous 5 events.

49ers vs. Raiders Predictions

Both teams are expected to bring in more starters, and since this is his first game is in Las Vegas, Carroll would like to win it, even if he has to use superstars more than planned. That’s why we pick the Raiders to triumph.

Free NFL picks: Raiders win -225

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.