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NFL Preseason Week 3: Chargers vs. 49ers Preview, Odds, Picks (Aug 23)

By · Updated 4 hours ago
  • Chargers vs. 49ers total is 35.5 points.
  • Trey Lance did well in the preseason.
  • Mac Jones is questionable, and we should see Brock Purdy in action.

The Chargers lost to the Rams last weekend by a point, while the 49ers beat the Raiders on the road by three. These two teams have grown accustomed to playing close matches and let’s hope this one will be like that too.

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How to Watch

  • When: Saturday, August 23, 8:30 pm ET
  • Where: Levi’s Stadium, San Francisco, California
  • How to Watch: ESPN Unlimited, CBS San Francisco

Chargers vs. 49ers Odds

TeamMoneylineSpreadTotals
Chargers-135-235.5
49ers+115+235.5

Game Preview

The LA Chargers had the best defense in the NFL during the 2024 season. That trend of rock-solid defense has continued throughout the preseason, and even though they’ve lost to the Rams, 23-22 last weekend, the LAC look well.

QB Trey Lance plays good football during the preseason, and he has 296 passing yards with 2 touchdowns, and he ran 81 yards on the ground, for one TD.

Speaking of quarterbacks, Mac Jones didn’t do well during the preseason, despite his high pass completion rate – 17-for-23, 209 yards, 0 TDs, and 2 picks. He is injured and will not participate in this event.

News suggests that RB Christian McCaffrey is in excellent shape and that his recent practices have shown significant progress. According to the ESPN reports, he is in mid-season form right now, and it’s quite possible to see him on the field for a couple of snaps.

Chargers vs. 49ers Head to Head

Right now, the all-time series are tied, with each team having 8 wins apiece.

Chargers vs. 49ers Predictions

LAC will play hard, while on the other hand, we should see the hosts with Purdy and CMC on the field. Still, the home team looks as the favorite to us, and we will pick the Niners to win.

Nikola Velickovic
Contributor Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.

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