NFL Week 12: Bills vs. Texans Preview, Odds, Picks (Nov 20)

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NFL Week 12: Buffalo Bills vs. Houston Texans Preview, Odds, Picks (Nov 20)

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Bills vs. Texans Preview, Odds, Prediction for the NFL week 12 game set at the NRG Stadium on November 20 and Thursday Night Football.

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Bills vs. Texans is NFL Week 12 Thursday Night Football.
The Buffalo Bills are the No. 1 rushing team in the NFL, averaging 147.6 yards per game.
Houston Texans are 3-1 in the last 4 games.

It’s the big-time AFC game between the Buffalo Bills and the Houston Texans. This event will have huge consequences for the playoff picture in this conference, as both sides must win.

How to Watch

When: Thursday, November 21, 8:15 pm ET
Where: NRG Stadium, Houston, Texas
How to Watch: Prime Video

Bills vs. Texans Odds

Team	Moneyline	Spread	Totals
Bills	-190	-3.5	43.5
Texans	+160	+3.5	43.5

Game Preview

The Buffalo Bills are back in the race for the top seed in the AFC East and the AFC, but they don’t have any room for error anymore. New England Patriots are two wins away, meaning Josh Allen and the boys are in a must-win situation.

This team holds the top spot in the league in rushing per game with 147.6 yards on the ground per game. They won three of their last four matches, with the most recent victory coming against the Buccaneers at home, 44-32.

JOSH ALLEN HAS 5 TOUCHDOWNS

THE BILLS RETAKE THE LEAD pic.twitter.com/N9OG1ALQNV
— Pay The Bills | A Trainwreck Sports Production (@PayTheBillsPod) November 16, 2025

The Houston Texans also have three triumphs in their recent 4 appearances, and are slowly getting back in the race for the postseason. Davis Mills starts at the quarterback instead of the injured CJ Stroud, and so far, the team has played well under his leadership.

Houston’s defense is the best in the league, allowing only 16.3 points per game, the fewest in the NFL. Also, they allow only 258.1 yards per game, which is the lowest figure in professional gridiron.

Bills vs. Texans Head to Head

Houston leads the all-time series, 7-5, with the last match taking place in October 2024, when the Texans defeated the Bills 23-20 at home.

Bills vs. Texans Predictions

The hosts are in solid shape, and their defense looks quite good. On the other hand, the Bills too are in very good form, and solely because of their better offense, we bet on their victory here. Mills or Stroud can’t be compared to Allen, and that’s what will make a difference here, despite Houston’s defense.

Free NFL Picks: Bills Win

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.