NFL Week 15: Titans vs. 49ers Preview, Odds, Picks (Dec 14)

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NFL Week 15: Tennessee Titans vs. San Francisco 49ers Preview, Odds, Picks (Dec 14)

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Titans vs. 49ers Preview, Odds, Prediction for the NFL week 15 game set at the Levi's stadium on December 14.

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Titans vs. 49ers odds heavily favor Niners, -950.
Tennessee has the worst offense in the league.
The TOTAL went OVER in 5 of the 49ers’ last 6 games.

This is a good chance for the 49ers to get the win and stay in the mix for the NFC West title. On the other hand, this could be a valuable teaching opportunity for the Titans.

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How to Watch

When: Sunday, December 15, 4:25 pm ET
Where: Levi’s Stadium, San Francisco, California
How to Watch: FOX

Titans vs. 49ers Odds

Team	Moneyline	Spread	Totals
Titans	+625	+12.5	44.5
49ers	-950	-12.5	44.5

Game Preview

Tennessee won last weekend, and they did so against one of the better defenses in the league. It was 31-29 for them against the Browns, in Cleveland, after a very tough finish in which Tennessee kept its composure and rebuffed the Browns’ two-point conversion attempt.

Cam Ward had a terrible passing session, completing only 14 of 28 passes for 117 yards, two touchdowns, and one interception. But the veteran RB, Tony Pollard, was there, with 161 rushing yards and two touchdowns.

"STONE. COLD. KITTLE."

Seven years ago today, George Kittle ERUPTED for 210 yards and an 85-yard TD in the first half against the Broncos for arguably the best performance from a TE in 49ers' history.

Ted Robinson was going CRAZY on the KNBR call ⬇️ pic.twitter.com/zReR38ZOmT
— KNBR (@KNBR) December 9, 2025

The 49ers also played their last game in Cleveland, and they too beat the Browns, 26-8, only two weeks ago. Kyle Shanahan’s boys had a week off, which came at the perfect time for these guys, who needed a bit of rest. A lot of the Niners will be injury-free after this break.

San Francisco’s defense isn’t near the top in any category, except allowed points. With 20.7 per game, they are the 8th scoring defense in the NFL, and to be honest, if it weren’t for that, with all Jones’ and Purdy’s meltdowns, the Niners wouldn’t be in the playoff race.

Titans vs. 49ers Head to Head

There have been just 15 games between these two franchises. The Niners lead the series, 9-6.

Titans vs. 49ers Predictions

Tennessee is at least two levels beneath the 49ers, who, truth be told, won’t spend too much energy here, yet rather save it for later. Their defense will drown Ward and the poor Titans’ O-line, and that’s quite enough for them to cover the spread.

Free NFL Picks: 49ers -12.5

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.