NFL Week 16: Bills vs. Browns Preview, Odds, Picks (Dec 21)

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NFL Week 16: Buffalo Bills vs. Cleveland Browns Preview, Odds, Picks (Dec 21)

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Bills vs. Browns Preview, Odds, Prediction, Pick for the NFL week 16 game at the Huntington Bank Stadium on December 21.

https://commons.wikimedia.org/wiki/File:FirstEnergy_Stadium_field_2016.jpg

Bills vs. Browns spread favors Buffalo by 10 points.
The TOTAL for this game is set at 42.5 points.
Myles Garrett needs one sack to reach the NFL record.

Bills have to win and verify the break from Fosborough last weekend. On the other side, the Browns are all about Garrett reaching the NFL sack record and Shedeur Sanders showing improvement.

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How to Watch

When: Sunday, December 21, 1 pm ET
Where: Huntington Bank Field, Cleveland, Ohio
How to Watch: CBS

Bills vs. Browns Odds

Team	Moneyline	Spread	Totals
Bills	-575	-10	42.5
Browns	+425	+10	42.5

Game Preview

Buffalo emerged victorious against New England on the road, 35-31, and is now again in contention not just for the AFC East title, but also for the No. 1 seed in the conference. Just to remind that the Bills came back from a 21-point deficit.

Josh Allen was laser-precise, throwing 3 touchdown passes despite only 193 passing yards. RB James Cook had 107 rushing yards for two scores, and the Bills overall had 169 rushing yards.

Total Touchdowns Before the Age of 30

Josh Allen                299🔥
Patrick Mahomes 263
Peyton Manning    253
Dan Marino             250
Matt Stafford         230
Brett Favre              229
Lamar Jackson       219
Jared Goff                214
#BillsMafia pic.twitter.com/olyJyiG03w
— Put Steve Tasker in the Hall of Fame (@HOFSteveTasker) December 15, 2025

The Browns experienced a brutal beating in Chicago, 31-3, and that perfectly reflects the situation on the field. Shedeur needs to step up, as he had a disastrous game here, throwing only for 177 yards, three picks, and suffering 5 sacks.

He ran for 24 yards, the most in Cleveland, which ended the night with 50 rushing yards. This was yet another reason for this terrible defeat. But at least Myles Garrett posted another sack, and now needs one more to level the record.

Bills vs. Browns Head to Head

After 23 games so far, the Browns lead 13-10.

Bills vs. Browns Predictions

The spread on the Bills is 10 points. But there’s another thing. This game will be all about Garrett and his NFL record. So instead of posting a regular bet, we will go with a prop, and that’s Garrett 2+ sacks here. Allen was sacked 33 times this season, and we’ve seen that the O-Line can’t protect him all the time, especially against top-level pass-rushers.

Free NFL Picks: Myles Garrett 2+ sacks

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.