NFL Week 17: Eagles vs. Bills Preview, Odds, Picks (Dec 28)

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NFL Week 17: Philadelphia Eagles vs. Buffalo Bills Preview, Odds, Picks (Dec 28)

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Eagles vs. Bills NFL week 15 Preview, Odds, Prediction, picks for the game set at the Highmark Stadium on December 28.

https://commons.wikimedia.org/wiki/File:Ralph_Wilson_Stadium_NFL_Buffalo_Bills_-_Orchard_Park,_NY.jpg

Eagles vs. Bills total is set at 43.5 points.
Philadelphia Eagles have the 3rd-best defense in the NFL, 19.3 points per game.
Buffalo Bills have 4 consecutive victories.

Both teams have a lot at stake here, noting that the Bills have slightly more than the Eagles. The situation in the AFC is very tense, and each win here is worth gold.

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How to Watch

When: Sunday, December 28, 4:25 pm ET
Where: Highmark Stadium, Orchard Park, New York
How to Watch: FOX

Eagles vs. Bills Odds

Team	Moneyline	Spread	Totals
Eagles	-105	+1.5	43.5
Bills	-115	-1.5	43.5

Game Preview

The Eagles are in the playoffs, but they are now battling to go up in the NFC and possibly reach the second seed and another home game in the Divisional Round. After a very negative period in late November and early December, the Super Bowl champs won back-to-back games.

Philly first beat the Raiders 31-0 at home, and then the division rivals, the Washington Commanders, 29-18 on the road. They are for sure the No.3 seed in the NFC, but reaching the second seed is possible, as the Bears have just one more win than they do.

Eagles/Bills 2023: The Hurts OT Walkoff

The Eagles were outplayed for much of the afternoon but never lost control of the moment and the game completely flipped in the fourth quarter.

The offense struggled, but Jalen Hurts took over after halftime, throwing 3 2nd half TDs,… pic.twitter.com/Xz7Fn4llxd
— Fly Eagles Fly Bets (@Fly_EaglesBets) December 23, 2025

The Bills are battling for the AFC East and the AFC top spot. But on the other side, they can easily drop down to place No.7. So they are under a lot of pressure here, and have to be at their best.

Regarding the form, Allen and the guys are in excellent shape, with 4 straight wins, three of them on the road, in Pittsburgh, Foxborough, and Cleveland. The sole home win was against the Bengals. So, yes, they are peaking.

Eagles vs. Bills Head to Head

In 15 matches, the Eagles have won 9 times and the Bills 6. Philly has three straight triumphs and five in the last 6.

Eagles vs. Bills Predictions

We pick the Bills here. They are in a must-win situation, and play very good. Eagles are improving, but their recent opponents were terrible teams, and given that the Bills are Super Bowl contenders, play at home, and are under pressure to win, we side with the hosts.

Free NFL Picks: Bills

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.