NFL Week 2: Broncos vs. Colts Preview, Odds, Picks (Sep 14)

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NFL Week 2: Broncos vs. Colts Preview, Odds, Picks (Sep 14)

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Broncos vs. Colts week 2 Preview, Odds, Prediction for the game set at the Lucas Oil Stadium on September 14.

https://commons.wikimedia.org/wiki/File:Lucas_Oil_Stadium_panoramic_view_from_south_end_suite_-_WCNA_Oct._2024.jpg

Broncos vs. Colts total points line is set at 42.5 points.
Denver Broncos limited the Titans to 133 yards in total last week.
Daniel Jones ran for two touchdowns against the Dolphins.

Danny Dimes madness has overwhelmed Indianapolis. We can’t imagine what will happen if he leads the Colts to a win over the Broncos.

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How to Watch

When: Sunday, September 14, 4:05 pm ET
Where: Lucas Oil Stadium, Indianapolis, Indiana
How to Watch: CBS

Broncos vs. Colts Odds

Team	Moneyline	Spread	Totals
Broncos	-135	-2.5	42.5
Colts	+115	+2.5	42.5

Game Preview

Bo Nix didn’t have a good performance against the Titans, completing 176 passing yards, one touchdown pass, and two interceptions. He even had a lost fumble, which, overall, should worry the Broncos’ fans.

However, the defense covered up all that. The Denver Broncos sacked Cam Ward 6 times, each time by a different defender. Hosts posted 12 QB hits, with Nik Bonitto posting three, as well as Zach Allen.

S/O to this defense 😤 pic.twitter.com/nB0fhal2Nm
— Denver Broncos (@Broncos) September 8, 2025

The Colts trashed the Miami Dolphins 33-8. QB Daniel Jones threw for 272 passing yards, having one TD pass. Yet that wasn’t his most significant achievement on Sunday. Danny Dimes ran for 2 touchdowns and emerged as the x-factor here.

Jonathan Taylor rushed 18 times for 71 yards, Michael Pittman Jr. had 80 receiving yards and one touchdown, and Tyler Warren had 76 receiving yards. Eventually, the Colts had almost twice as many total yards as the Dolphins, 418 to 211.

Broncos vs. Colts Head to Head

The overall score between these two teams is tied at 15 wins each. We’ve seen them play last season, when Denver beat the Colts 31-15 at the Mile High.

Broncos vs. Colts Predictions

The Denver Broncos have a terrifying defense, but on the other side, their quarterback still oscillates. That’s the sole reason why we give the Colts an edge in this one. Jones and the versatile offense, the Colts will go toe to toe with the Broncos’ defense, but on the other hand, Nix will have plenty of problems to find his rhythm.

Free NFL picks: Colts win

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.