NFL Week 4: Seahawks vs. Cardinals Preview, Odds, Picks (Sep 25)

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NFL Week 4: Seahawks vs. Cardinals Preview, Odds, Picks (Sep 25)

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Seahawks vs. Cardinals Week 4 Preview, Odds, Prediction for the game set at the State Farm Stadium on September 25 on Thursday Night Football.

https://commons.wikimedia.org/wiki/File:Phoenix_-_State_Farm_Stadium_-_IMG_8244_51576996287.jpg

Seahawks vs. Cardinals TNF moneyline is even.
Cardinals RB James Conner is out for the season due to an ankle injury.
The Seattle Seahawks have won the last 7 games against the Cardinals.

The NFC West will be electric this year, because all 4 teams attack the NFL playoffs. As a divisional rivalry, this matchup will have a huge impact on the final standings.

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How to Watch

When: Thursday, September 25, 8:15 pm ET
Where: State Farm Stadium, Glendale, Arizona
How to Watch: Prime Video

Seahawks vs. Cardinals Odds

Team	Moneyline	Spread	Totals
Seahawks	-110	EVEN	43.5
Cardinals	-110	EVEN	43.5

Game Preview

Seattle’s offense had a light practice against the Saints this Sunday afternoon, winning this event 44-13. WR Tory Horton made a play of the game when he returned the punt all the way to the endzone, for 95 yards. He had one more receiving TD later, ending the game with 114 returning yards and 32 receiving.

Kenneth Walker III rushed for two scores, while Sam Darnold threw 218 yards for 2 TD passes, completing 14 of his 18 pass attempts.

Seattle WR Tory Horton with a 95-yard punt return — the longest punt return in Seahawks history. pic.twitter.com/4IxRYo9Xm2
— Adam Schefter (@AdamSchefter) September 21, 2025

The Cardinals have not just suffered a defeat to the Niners (16-15) via field goal as time expired, but they also lost James Conner for the rest of the season. The strong running back injured his ankle, and this is a massive blow for the Cards.

What does this mean for all the NFL bettors? First, the backup RB, Trey Benson, will have to step up. Secondly, we expect to see Murray running even more than before. Keep this in mind when making some NFL prop bets or anything similar.

Seahawks vs. Cardinals Head to Head

The overall record is on Seattle’s side, 29-22-1. Also, the Seahawks have 7 wins in a row. Last year, they were better at Lumen Field, 16-6, and in Arizona, 30-18.

Seahawks vs. Cardinals Predictions

It’ll be tough for the Cards to balance their game without Conner, particularly against the Seahawks’ defense, which has been solid so far. We will be risky here and go with Seattle to triumph.

Free NFL picks: Seahawks win

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.