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NFL Week 5: 49ers vs. Rams Preview, Odds, Picks (Oct 2)

By · Updated 19 hours ago
  • 49ers vs. Rams is the NFL Week 5 Thursday Night Football.
  • The total in this game is set at 47.5 points.
  • The Rams are favorites at -225.

Banged-up Niners visit their NFC West rivals, the LA Rams, coming as underdogs in this one with a very shaky Brock Purdy, who is under heavy pressure to start playing at the expected level.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Thursday, October 2, 8:15 pm ET
  • Where: SoFi Stadium, Los Angeles, California
  • How to Watch: Prime Video

49ers vs. Rams Odds

TeamMoneylineSpreadTotals
49ers+190+4.547.5
Rams-22543.547.5

Game Preview

Numerous injuries have hit the Niners, and according to the latest info, WR Ricky Pearsall and QB Brock Purdy are questionable for TNF. To be honest, Purdy’s absence won’t be felt that much, as he has constantly underachieved this year. In 4 matches, he has 4 touchdown passes and the same number of interceptions.

We’ll be straight with you; he isn’t the starter material, and without the team’s help, that’s visible. Mac Jones should be back; his numbers are way better, with 563 passing yards in two games, and 4 TD passes with one pick.

Rams bounced back following a loss in Philly, beating the best offense in the league until Week 4, the Indianapolis Colts, 27-20. Their defense forced three turnovers, with the safety Kam Curl recording two interceptions.

Meanwhile, Matt Stafford threw for 375 yards and 3 touchdowns, with his favorite target being WR Puka Nacua, who had one touchdown reception and an incredible 170 yards from 13 catches.

49ers vs. Rams Head to Head

After 152 games, the record is on San Francisco’s side, 78-71-3.

49ers vs. Rams Predictions

Whoever starts here for the Niners won’t be able to save them from an inevitable defeat. The Rams play at home, have a healthier squad, and simply look way better than the 49ers.

Nikola Velickovic
Contributor Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.