NFL Week 6: Patriots vs. Saints Preview, Odds, Picks (Oct 12)

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NFL Week 6: Patriots vs. Saints Preview, Odds, Picks (Oct 12)

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Patriots vs. Saints week 6 Preview, Head to Head, Picks, Odds, Prediction for the game set at the Caesars Dome on October 12.

https://commons.wikimedia.org/wiki/File:Louisiana_Superdome,_New_Orleans,_Louisiana_3938534682.jpg

Patriots vs. Saints odds favor New England at -185.
Spencer Rattler posted his first NFL win, 26-14 vs. Giants.
The New England Patriots won Monday Night Football in Buffalo, 23-20.

Both teams are hyped following last weekend, as they posted big-time wins. The Pats have defeated the Bills in Buffalo, while the Saints beat the Giants at home.

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How to Watch

When: Sunday, October 12, 1 pm ET
Where: Caesars Superdome, New Orleans, Louisiana
How to Watch: CBS

Patriots vs. Saints Odds

Team	Moneyline	Spread	Totals
Patriots	-185	-3.5	46.5
Saints	+155	+3.5	46.5

Game Preview

New England is now officially challenging the Bills for the AFC East title. A 23-20 win in Buffalo shows that Mike Vrabel’s crew has what it takes to attack the playoffs. QB Drake Maye showed a glimpse of elite talent, completing 273 passing yards without any touchdowns or interceptions, while handling the situation like a pro.

Rhamondre Stevenson ran for just 14 yards but had two touchdowns, while Stefon Diggs exploded, having 10 catches against his former team for 146 receiving yards.

🚨🚨HELL OF A PERFORMANCE🚨🚨#Patriots cornerback Christian Gonzalez SHUT DOWN all the #Bills receivers tonight.

• 44 Coverage Snaps
• 5 Targets
• 2 Total Catches Allowed
• One Pass Break Up
• 6 Tackles

He is only 23 🔒🔒🔒

AGENT ZERO. THE BEST CORNERBACK IN THE #NFL. pic.twitter.com/oQH7ktDvi1
— MLFootball (@_MLFootball) October 6, 2025

Spencer Rattler finally got his first win as a starter in the NFL. The Saints beat the Giants 26-14, with him passing for 225 yards, one touchdown, and adding 21 more yards on the ground. WR Rashid Shaheed had 114 receiving yards, for one touchdown and one 87-yard explosion.

We must acknowledge that numerous injuries plagued the Giants, but that won’t diminish New Orleans’ success. This is the Saints’ first triumph of the year.

Patriots vs. Saints Head to Head

Two years ago, the Saints inflicted one of the worst defeats on the Pats at Gillette Stadium, 34-0. The all-time record is on New England’s side, 10-6.

Patriots vs. Saints Predictions

The Pats have been steady this season, and they are looking better and better as time goes by. New Orleans plays at home and is very fired up ahead of this one, but we have to go with the guests, who have a much more balanced game on both sides of the field.

Free NFL Picks: New England Patriots Win

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.