NFL Week 7: Colts vs. Chargers Preview, Odds, Picks (Oct 19)

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NFL Week 7: Colts vs. Chargers Preview, Odds, Picks (Oct 19)

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Colts vs. Chargers preview, Head to Head, Odds, Predictions, picks for the NFL Week 7 game set at the SoFi Stadium on October 19.

https://commons.wikimedia.org/wiki/File:SoFi_Stadium_interior_2021.jpg

Colts vs. Chargers odds are almost even.
Indianapolis Colts are the No.1 offense in the NFL with 32.3 points per game.
The Chargers are battling with injuries, yet are 4-2 heading into Week 7.

These two teams can easily meet in the playoffs. While the Chargers have problems with injuries and can’t shake them off, the Colts are on fire, having the best offense in the NFL ahead of Week 7.

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How to Watch

When: Sunday, October 19, 4:05 pm ET
Where: SoFi Stadium, Inglewood, California
How to Watch: CBS

Colts vs. Chargers Odds

Team	Moneyline	Spread	Totals
Colts	+110	+1.5	48.5
Chargers	-130	-1.5	48.5

Game Preview

The fact that the Colts are the best offense in the NFL tells us a lot about them. This team is 5-1 and has arguably the best running back, Jonathan Taylor, who already has 603 rushing yards and 7 touchdowns on the ground.

‘They also have one of the best offensive lines in the NFL, which allowed only 5 sacks on QB Daniel Jones. “Danny Dimes” threw for 1,502 passing yards and 8 touchdowns with three interceptions. He has two more running touchdowns as well.

I’m a believer in this Colts team. If it wasn’t for a dropped ball through the endzone they would be undefeated. A great RB and run game, a QB who is playing his best and most efficient football and a Defense that is disciplined and talented. They are contenders!
— Richard Sherman (@RSherman_25) October 12, 2025

As for the Chargers, Najee Harris’ injury really shook them, but Jonathan Taylor once again proves his worth leading a winning drive. This time it was in Miami where LAC beat the Dolphins, 29-27. Herbert threw for 264 yards and 2 touchdowns.

Kicker Cameron Dicker was perfect from the field, hitting all of his 5 field goals, including the 33-yard one with 5 seconds left, when he put the Chargers ahead and set the final result.

Colts vs. Chargers Head to Head

The two sides met 31 times, and the Chargers lead the series, 20-11.

Colts vs. Chargers Predictions

The Indianapolis Colts are an offensive machine, and right now, even though we respect the Chargers, we have to side with the guests in this one. The Chargers have plenty of injuries on the offensive side, primarily among the runners, and that will take a toll. In short, we don’t think that the hosts can keep up the offensive rhythm with the Colts.

Free NFL Picks: Colts Win

Nikola Velickovic Contributor

Nikola is one of those rare fanatics who dedicated their lives to sports. In the last five years, he has worked as a betting tips writer for several companies. Also, he does coverage of various sports events, and besides his betting skills, he is a sports news contributor on multiple websites. Here at VegasOdds, Nikola is in charge of the NBA, Champions League and the world’s most famous soccer competition the English Premier League.