Panthers vs. Saints Prediction: Odds, Spread and Best Bets for Week 10

The NFC South is one of the weakest but most entertaining divisions in the NFL. Every team has a losing record, and every team is still in the race for the division title and a playoff spot. This Sunday, it’s Panthers vs. Saints in New Orleans.

Both teams are 3-5 and tied at the top of the division, as crazy as that sounds, and both have a negative point differential. The game is a pick’em, so we should be in for a fun one in Louisiana.

For our pick on every game this week, check out our NFL Week 10 picks against the spread.

Sunday, November 15 | 1:00 PM ET | Caesars Superdome, New Orleans, LA | FOX

Panthers vs. Saints Week 10 Odds

Team	Spread	ML	Total
Panthers	Pk	+103	O 49
Saints	Pk	-123	U 49

Odds from BetOnline as of Tuesday, November 10. For the latest lines on every game, see our NFL odds page.

There’s no spread here, so this is a straight pick’em, with the Panthers at +103 and the Saints at -123. That gives the hosts an implied win probability of around 55%. The big mover is the total, which has climbed from 43.5 to 49 since the lines opened, so the market expects a shootout.

Panthers Odds and Form: Defense Holds the Key

The Panthers have flaws on offense, but they’re putting up points. Bryce Young is playing the best football of his career, and the offense looks far better than it did. The problem is protection. Young has already been sacked more than 20 times, including three times in last week’s 26-21 home loss to the Broncos.

There’s a good balance between the pass and the run, with Chuba Hubbard having a strong season (619 rushing yards so far), though he’s the only reliable back on the depth chart.

Defense is what will decide Carolina’s playoff hopes. The Panthers allow 27.4 points per game and are poor against the run, giving up 133.4 rushing yards per game, 28th in the NFL. The secondary is solid, but teams have been able to move the chains on the ground all season.

Saints Odds and Form: It’s Time for Kellen Moore

Kellen Moore is one of the best offensive minds in the NFL, and this is his chance to show it. The Saints have struggled to run the ball, but Alvin Kamara should be fully fit for this game. Audric Estime, third on the depth chart, also impressed against the Browns with 72 yards and a touchdown on 15 carries. Add Tyler Shough’s legs, and the Saints suddenly have a real ground game.

With a balanced offense for the first time in weeks, Moore has what he needs to get creative. The Saints’ defense is limited, so the offense has to win this game.

After a fast start, New Orleans’ offense faded, mainly because of injuries and a lack of reliable running backs. Last week showed what this team can do with a healthy back against a respectable Browns defense, so there’s no reason it can’t do the same against Carolina’s leaky run defense.

Panthers vs. Saints Predictions: Best Bets

Over/Under Pick: Over 49

Both teams are built offense-first, mainly because neither defense can be trusted. Carolina ranks 28th against the run, the Saints’ defense ranks in the bottom five overall, and the game is in a dome, with ideal conditions for two quarterbacks who like to throw.

We’re only making one pick here. With the game a pick’em and both teams so evenly matched, the side is close to a coin flip, so we’d rather put our money where the edge is: on points.

• Poor defenses. These teams have the 27th- and 28th-ranked defenses in the NFL.
• Indoor conditions. Both offenses lean on the pass, and the Superdome takes weather out of the equation.

How to Bet on Panthers vs. Saints

Want to back our Panthers vs. Saints pick? The sportsbooks below accept US players and post odds on every NFL game as soon as the lines are released, with spreads, moneylines and totals for this NFC South showdown all available well before Sunday.

1. Pick a sportsbook from the table below and create your account.
2. Make your first deposit and claim the welcome offer.
3. Find the game under NFL in the sportsbook menu, listed with the Sunday 1 PM ET kickoffs.
4. Choose your bet, whether that’s the Over 49, the moneyline or both, enter your stake and confirm.

The total has already jumped from 43.5 to 49 and is still trending up. If you like the Over, it’s worth getting in before it climbs any higher.

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