NHL Betting Picks: Best Bets For All Games on Oct 21, 2026
A quiet evening of NHL action is set for Oct 21, as just two games are scheduled. The Buffalo Sabres host the Philadelphia Flyers, while the Florida Panthers travel to the Ottawa Senators. You can find our selections for both games, as well as our NHL betting picks for a value play and one selection to fade below.
NHL Betting Picks: Best Bets Today & Top Value Picks
- Best Pick: Ottawa Senators (vs. Florida Panthers)
- Best Value: Buffalo Sabres (vs. Philadelphia Flyers)
- Team to Fade: Philadelphia Flyers (@ Buffalo Sabres)
- Best NHL Parlay Bet: Ottawa Senators & Philadelphia Flyers @ Buffalo Sabres (Over 6.5 Goals)
ALSO SEE: Breeders’ Cup Classic Picks, Odds, Leading Contenders, Betting Insights & Analysis
NHL Best Bets Today: Key Game Breakdown & Predictions
Philadelphia Flyers @ Buffalo Sabres Prediction & Odds
Date: Wednesday, October 21 | KeyBank Center, Buffalo
Game Preview
There will be confidence within the Philadelphia Flyers team on Wednesday, as they have recorded back-to-back wins against the Ottawa Senators and Colorado Avalanche. That has been the perfect response after losing seven on the bounce.
However, their attacking output is still a concern, with their 1.55 goals per game being the 32nd best offense in the NHL. The Buffalo Sabres boast excellent offensive output in the forms of Jack Quinn and Tage Thompson, and they should be well-rested following an overtime loss at the hands of the Montreal Canadiens from the weekend.
- Best Bet: Buffalo Sabres
Florida Panthers @ Ottawa Senators Prediction & Odds
Date: Wednesday, October 21 | Canadian Tire Centre, Ottawa
Game Preview
The Florida Panthers have hit their stride after winning three on the bounce, which includes a recent 8-3 home win against the Seattle Kraken. However, the Ottawa Senators should present the value in the betting this week after enjoying a red-hot start to the new season.
The Senators have gone 5-2-0 in the NHL, showcasing an excellent ability in front of their own fans, winning three of their last four at Canadian Tire Centre. Therefore, the home win is a value play when considering the best NHL betting picks on Tuesday.
- Best Bet: Ottawa Senators
Best NHL Betting Picks For Every Game on Oct 21, 2026
| NHL Game | NHL Betting Picks |
|---|---|
| Florida Panthers @ Ottawa Senators | Ottawa Senators |
| Philadelphia Flyers @ Buffalo Sabres | Buffalo Sabres |
How to Bet On NHL Today
These are the best sportsbooks for U.S. bettors to place wagers on the NHL today:
