Liga MX Predictions: Best Bets, Odds & Picks For Apertura Matchday 16

By · Updated 9 minutes ago

Best pick: Atletico de San Luis vs. FC Juarez, San Luis (-134)

Best over/under: Tigres vs. Cruz Azul, Over 2.5 Goals (+103)

Liga MX parlay: San Luis, Queretaro, Club America (+570)

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The Apertura is down to its final two weekends, and Matchday 16 is packed with games that matter, from the four-way fight for first place to teams scrambling for a playoff spot. We’ve gone through all nine matchups and have our best pick, our favorite over/under and a three-leg parlay for the weekend, plus a pick for every game.

Free Liga MX Betting Picks for Matchday 16

The full slate of nine games runs from Friday to Sunday. Here are our picks for the standout matchups.

Atletico de San Luis vs. FC Juarez Prediction & Odds

Friday, November 6 | 8:00 PM ET | Estadio Alfonso Lastras, San Luis

TeamMoneylineSpreadTotal
Atletico de San Luis-134-0.75 (-108)Over 2.5 (-135)
Draw+294
FC Juarez+348+0.75 (-117)Under 2.5 (+105)

Odds from BetOnline, checked Nov 4.

Atletico de San Luis is our best bet of the weekend. San Luis has found some form at the right time, winning two of its last three, including a gritty 1-0 win over Atlante where the defense didn’t give an inch. Juarez has been one of the weakest teams in Liga MX this season and has failed to win in five of its last six. At home, against a team in that kind of slump, we like San Luis to get the job done at -134.

UNAM Pumas vs. Club America Prediction & Odds

Saturday, November 7 | 10:10 PM ET | Estadio Olimpico Universitario, Mexico City

TeamMoneylineSpreadTotal
UNAM Pumas+222+0.5 (-153)Over 3 (-114)
Draw+260
Club America+117-0.5 (+117)Under 3 (-112)

Odds from BetOnline, checked Nov 4.

Club America has been the team to beat all Apertura, but it needs a win here to stay ahead of Guadalajara, Cruz Azul and Atlas in a four-way race for first place. The form is a worry, with no wins in three and back-to-back draws against Tijuana and Toluca. But Pumas has failed to win four of its last five, and America has too much quality not to take advantage. At +117, getting plus money on the league’s best team is a price we’ll take.

Tigres UANL vs. Cruz Azul: Our Best Over/Under Pick

Cruz Azul is right in the title race and can’t afford to sit back in Monterrey, and Tigres will want to make a statement at home with the playoffs around the corner. With both teams needing something from this game, we expect it to open up, and Over 2.5 goals at +103 is close to even money for a game we think has goals in it.

Liga MX Picks Against the Spread

The spread can be a great way to find value in soccer. With a -1 line, your team needs to win by two or more goals for the bet to win. If it wins by exactly one, it’s a push and you get your stake back. Here’s our best Liga MX pick against the spread this weekend.

Toluca -1 (-101) vs. Monterrey: Toluca is always tough at home, with the altitude giving it a real edge over visiting teams. Monterrey has struggled on the road all season, losing three of its six away games, and we think Toluca wins this one comfortably.

Liga MX Parlay Picks This Weekend

Combining legs is a fun way to boost your payout, and these three picks make a strong Liga MX parlay for Matchday 16:

  1. Atletico de San Luis (-134)
  2. Queretaro (-130)
  3. Club America (+117)

Parlay odds: +570 | $100 returns $670

Liga MX Picks for Every Game This Weekend

Liga MX MatchOur PickOdds
Club Necaxa vs. Club TijuanaClub Necaxa+126
Atletico de San Luis vs. FC JuarezAtletico de San Luis-134
Atlante vs. Santos LagunaSantos Laguna+214
Atlas FC vs. PachucaUnder 2.5 Goals-140
Tigres UANL vs. Cruz AzulCruz Azul+131
Toluca vs. MonterreyToluca-156
Pumas UNAM vs. Club AmericaClub America+117
Queretaro vs. Club PueblaQueretaro-130
Club Leon vs. GuadalajaraGuadalajara+117

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Alex Dudley
Contributor Alex has covered huge sporting events for various websites and publications. He has attended football European Championships, Rugby League and Union World Cups, and the Paralympics. Alex is dedicated to giving the most insightful tips for VegasOdds readers and specialises in horse racing, soccer, golf and basketball.

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