MLS Predictions: Decision Day Best Bets, Odds & Picks for Saturday, Nov 7
Best pick: Inter Miami vs. Charlotte FC, Inter Miami (-270)
Best BTTS: CF Montreal vs. Vancouver Whitecaps, Yes (-200)
Best over/under: FC Cincinnati vs. Nashville SC, Under 3.5 Goals (-137)
MLS parlay: Inter Miami, Philadelphia, Vancouver, Nashville (+802)
Claim Up to $250 Free Bet at BetOnlineIt’s Decision Day in MLS. All 15 games kick off on Saturday, and the last playoff spots in both conferences are on the line. We’ve been through the full slate and have our best pick, our favorite both teams to score bet, the best over/under and a four-leg parlay, plus a pick for every game.
Free MLS Betting Picks for Decision Day
Here are our picks for the standout matchups on the final day of the regular season.
Inter Miami vs. Charlotte FC: Our Best Pick
Inter Miami has been one of the best teams in MLS all season, and Lionel Messi has been the reason why, with 26 goals in 30 league appearances in 2026. At home on Decision Day, with Messi leading the line, we like Miami to finish the regular season with a win. At -270 it’s a short price, which is why it’s also the anchor leg of our parlay.
FC Cincinnati vs. Nashville SC Prediction & Odds
Saturday, November 7 | 4:00 PM ET | TQL Stadium, Cincinnati, OH
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| FC Cincinnati | +137 | -1.0 (+350) | Over 3.5 (+104) |
| Draw | +286 | ||
| Nashville SC | +170 | +1.0 (-188) | Under 3.5 (-137) |
Odds from BetOnline, checked Nov 4.
Nashville is set to lift the Supporters’ Shield on Saturday, but its season will be judged on what happens in the playoffs. Cincinnati has a lot more riding on this one, because only a win guarantees a spot in the first round.
Cincinnati’s recent form has been mixed, and with so much at stake, we don’t expect them to throw caution to the wind. That’s why we like the Under 3.5 goals at -137 as our best over/under of the day. Four or more goals is a big ask in a game where one side has to be careful and the other has nothing to prove. We also like Nashville at +170 to win, because a team playing free of pressure is a dangerous opponent for a side that’s feeling it.
CF Montreal vs. Vancouver Whitecaps: Our Best BTTS Pick
Vancouver is the favorite on the road at -148, and it’s also one of our parlay legs, but we expect Montreal to find the net too. Both teams to score at -200 is our best BTTS pick on the Decision Day slate.
Real Salt Lake vs. LA Galaxy Prediction & Odds
Saturday, November 7 | 7:00 PM ET | America First Field, Sandy, UT
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| Real Salt Lake | -160 | -1.0 (-102) | Over 3.5 (-103) |
| Draw | +354 | ||
| LA Galaxy | +365 | +1.0 (-123) | Under 3.5 (-126) |
Odds from BetUS, checked Nov 4.
The last first-round spot in the West comes down to this game. The Galaxy hold it going into the final day, so Real Salt Lake needs a win to have any chance of overtaking them.
The Galaxy are unbeaten in four, but RSL has won three of its last four, and LA has been poor on the road all year, losing seven of its 16 away games. With a playoff spot riding on it, and the home crowd behind them, we like Real Salt Lake at -160.
MLS Picks Against the Spread
The spread can be a great way to find value in soccer. With a -0.5 line, your team simply needs to win. A draw or a loss means the bet loses. Here’s our best MLS pick against the spread on Decision Day.
Minnesota United -0.5 (-135) vs. San Jose Earthquakes: Minnesota has lost just once in its last six and has been excellent defensively at home, which gives it a strong platform here. San Jose has failed to win nine of its 16 road games, and we expect Minnesota to finish the regular season on a high.
MLS Parlay Picks for Decision Day
Combining legs is a fun way to boost your payout, and these four picks make a strong MLS parlay for the final day of the regular season:
- Inter Miami to win (-270)
- Philadelphia Union to win (-220)
- Vancouver Whitecaps to win (-148)
- Nashville SC to win (+170)
Parlay odds: +802 | $100 returns $902
MLS Picks for Every Game on Decision Day
| MLS Match | Our Pick | Odds |
|---|---|---|
| CF Montreal vs. Vancouver Whitecaps | Vancouver Whitecaps | -148 |
| Chicago Fire vs. Columbus Crew | Over 3.5 Goals | +106 |
| D.C. United vs. New York City FC | New York City FC | +126 |
| FC Cincinnati vs. Nashville SC | Nashville SC | +170 |
| Inter Miami vs. Charlotte FC | Inter Miami | -270 |
| New York Red Bulls vs. Atlanta United | New York Red Bulls | -115 |
| Orlando City vs. New England Revolution | Over 3.5 Goals | -119 |
| Philadelphia Union vs. Toronto FC | Philadelphia Union | -220 |
| Austin FC vs. Portland Timbers | Portland Timbers | -147 |
| FC Dallas vs. Colorado Rapids | FC Dallas | +108 |
| Houston Dynamo vs. St. Louis City | Houston Dynamo | +148 |
| Minnesota United vs. San Jose Earthquakes | Minnesota United | -135 |
| Real Salt Lake vs. LA Galaxy | Real Salt Lake | -160 |
| San Diego FC vs. Sporting KC | San Diego FC | -220 |
| Seattle Sounders vs. LAFC | LAFC | +265 |
How to Bet on MLS This Week
Ready to put our MLS picks into action? These sportsbooks all accept US players and cover every Decision Day game, with moneylines, spreads, totals, both teams to score and parlays on the full slate. New players can also claim a welcome bonus on their first deposit.
