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US Open: Karolina Muchova vs. Naomi Osaka Picks, Odds, and Preview (Sep 3)

By · Updated 2 days ago

A fascinating quarterfinal clash at the US Open is set for Sep 3, 2025, as the resurgent Naomi Osaka takes on eleventh-seed Karolina Muchova. But, which player will progress through to the final four? Find our picks here.


How To Watch

  • When: Wednesday, September 3, 2025, at TBA
  • Where: USTA Billie Jean King National Tennis Center
  • How To Watch: ESPN

Karolina Muchova vs. Naomi Osaka Odds

PlayerOdds
Karolina Muchova+192
Naomi Osaka-230

Head-to-Head Record

The players are locked level on two wins apiece from the four previous encounters. However, Osaka did land a three sets win in the latest clash between the stars at the Australian Open earlier this calendar year.


Match Preview

It has been a welcome return to form for the two-time US Open champion Naomi Osaka at Flushing Meadows this year. The Japanese star has looked incredible in New York, and she could have emerged as the main danger to the top seeds for Grand Slam glory in 2025.

Osaka’s resurgence hit a new level on Monday, as she stormed past American hope Coco Gauff in straight sets. The Japanese former world number one dropped just five games, and won a staggering 94% of the points on first serve. She was also clinical, converting on four of four break point opportunities.

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Karolina Muchova has been somewhat of a US Open specialist in recent years, reaching the semi-finals in each of the last two editions. Her win rate at the Slam of 71% deserves respect, and she will have hopes of reaching a second Grand Slam final this year.

Muchova’s US Open campaign kick-started with a victory over Venus Williams, but she has been workwoman-like throughout the tournament. She has required three sets in every round of the competition to this point. In the previous round, she overcame Marta Kostyuk, but in total, she conceded ten break point opportunities.


Karolina Muchova vs. Naomi Osaka Picks

Muchova’s battling qualities deserve respect, but the fact that she has stuttered through on occasions is a concern against a red-hot opponent. Therefore, the preference is for Osaka to continue her dream run at the US Open.

Free Picks:

Alex Dudley
Contributor Alex has covered huge sporting events for various websites and publications. He has attended football European Championships, Rugby League and Union World Cups, and the Paralympics. Alex is dedicated to giving the most insightful tips for VegasOdds readers and specialises in horse racing, soccer, golf and basketball.