NBA: 76ers vs. Knicks Opening Night Preview, Odds, Picks (Oct 20)

• 76ers vs. Knicks NBA odds favor New York at -200.
• Philly has a super team with LeBron, Jaylen Brown, and Anfernee Simmons landing during the offseason.
• Knicks replaced Mitchell Robinson with Andre Drummond.

Knicks are the world champions, and as such, they open the 2026/26 NBA season at MSG. First opponent: the newly formed super team – Philadelphia 76ers.

Here are more NBA expert picks, with the latest odds and more info.

How to Watch

• When: Tuesday, October 20, 2026, 7:00 PM ET
• Where: Madison Square Garden, New York, NY
• How to Watch: NBC, Peacock, MSG Network, NBC Sports Philadelphia

76ers vs. Knicks Odds

Game Preview

What a summer for Philadelphia. They not only signed LeBron, but Jaylen Brown too, forming not a super team, but an ultra-team. They have the highest star power of any unit in the NBA, and now everything is on Nick Nurse to fit it all together.

The Sixers lost all three preseason games, but they used them to help the players get to know one another better. We don’t have much to say about this team, because their individual quality is the best in the NBA.

Now, when reading all this, many would think that the Knicks enter this one as the NBA underdog. But the reality is different, and the champs are solid favorites to win.

They didn’t change the team’s core at all, losing only Mitchell Robinson and signing veteran center Andre Drummond, who played in Philly. Drummond was solid in NYK’s win over the Raptors, 122-120, in the last preseason game, scoring 14 points in 15 minutes with 8 boards and 4 assists.

76ers vs. Knicks Predictions

Philadelphia has huge offensive potential, but it will need time to click. The same goes for the defense. No matter how much we respect LeBron, Embiid, Maxey, Brown, and the boys, we’re putting our money on the Knicks.

• Free NBA pick for tonight: Knicks