Liga MX Predictions: Best Bets, Odds & Picks For Apertura Matchday 16

The Apertura is down to its final two weekends, and Matchday 16 is packed with games that matter, from the four-way fight for first place to teams scrambling for a playoff spot. We’ve gone through all nine matchups and have our best pick, our favorite over/under and a three-leg parlay for the weekend, plus a pick for every game.

Free Liga MX Betting Picks for Matchday 16

The full slate of nine games runs from Friday to Sunday. Here are our picks for the standout matchups.

Atletico de San Luis vs. FC Juarez Prediction & Odds

Friday, November 6 | 8:00 PM ET | Estadio Alfonso Lastras, San Luis

Team	Moneyline	Spread	Total
Atletico de San Luis	-134	-0.75 (-108)	Over 2.5 (-135)
Draw	+294
FC Juarez	+348	+0.75 (-117)	Under 2.5 (+105)

Odds from BetOnline, checked Nov 4.

Atletico de San Luis is our best bet of the weekend. San Luis has found some form at the right time, winning two of its last three, including a gritty 1-0 win over Atlante where the defense didn’t give an inch. Juarez has been one of the weakest teams in Liga MX this season and has failed to win in five of its last six. At home, against a team in that kind of slump, we like San Luis to get the job done at -134.

UNAM Pumas vs. Club America Prediction & Odds

Saturday, November 7 | 10:10 PM ET | Estadio Olimpico Universitario, Mexico City

Team	Moneyline	Spread	Total
UNAM Pumas	+222	+0.5 (-153)	Over 3 (-114)
Draw	+260
Club America	+117	-0.5 (+117)	Under 3 (-112)

Odds from BetOnline, checked Nov 4.

Club America has been the team to beat all Apertura, but it needs a win here to stay ahead of Guadalajara, Cruz Azul and Atlas in a four-way race for first place. The form is a worry, with no wins in three and back-to-back draws against Tijuana and Toluca. But Pumas has failed to win four of its last five, and America has too much quality not to take advantage. At +117, getting plus money on the league’s best team is a price we’ll take.

Tigres UANL vs. Cruz Azul: Our Best Over/Under Pick

Cruz Azul is right in the title race and can’t afford to sit back in Monterrey, and Tigres will want to make a statement at home with the playoffs around the corner. With both teams needing something from this game, we expect it to open up, and Over 2.5 goals at +103 is close to even money for a game we think has goals in it.

Liga MX Picks Against the Spread

The spread can be a great way to find value in soccer. With a -1 line, your team needs to win by two or more goals for the bet to win. If it wins by exactly one, it’s a push and you get your stake back. Here’s our best Liga MX pick against the spread this weekend.

Toluca -1 (-101) vs. Monterrey: Toluca is always tough at home, with the altitude giving it a real edge over visiting teams. Monterrey has struggled on the road all season, losing three of its six away games, and we think Toluca wins this one comfortably.

Liga MX Parlay Picks This Weekend

Combining legs is a fun way to boost your payout, and these three picks make a strong Liga MX parlay for Matchday 16:

1. Atletico de San Luis (-134)
2. Queretaro (-130)
3. Club America (+117)

Parlay odds: +570 | $100 returns $670

Liga MX Picks for Every Game This Weekend

Liga MX Match	Our Pick	Odds
Club Necaxa vs. Club Tijuana	Club Necaxa	+126
Atletico de San Luis vs. FC Juarez	Atletico de San Luis	-134
Atlante vs. Santos Laguna	Santos Laguna	+214
Atlas FC vs. Pachuca	Under 2.5 Goals	-140
Tigres UANL vs. Cruz Azul	Cruz Azul	+131
Toluca vs. Monterrey	Toluca	-156
Pumas UNAM vs. Club America	Club America	+117
Queretaro vs. Club Puebla	Queretaro	-130
Club Leon vs. Guadalajara	Guadalajara	+117

How to Bet on Liga MX This Week

Ready to put our Liga MX picks into action? These sportsbooks all accept US players and cover every Liga MX game, with moneylines, spreads, totals and parlays on the full slate. New players can also claim a welcome bonus on their first deposit.

Sportsbook ratings

#SportsbookOur ratingRegionsWelcome offerMin depositActions

1

BetOnline

Our rating 9.8/10

Regions🇦🇺Australia🇨🇦Canada🇺🇸United States

No Strings Welcome Offer50% up to $250

Minimum deposit$10 Crypto

Review Bet Now

2

BetUS

Our rating 9.8/10

Regions🇨🇦Canada🇺🇸United States

Welcome Bonus125% up to $2500

Minimum deposit$100

Review Bet Now

3

Bookmaker

Our rating 9.4/10

Regions🇨🇦Canada🇺🇸United States

Crypto Bonus20% Cash up to $500

Minimum deposit$50 (card) / $100 (crypto)

Review Bet Now

4

BetAnything

Our rating 8.7/10

Regions🇨🇦Canada🇺🇸United States

Free Play100% up to $500

Minimum deposit$20

Review Bet Now

5

BetWhale

Our rating 8.6/10

Regions🇨🇦Canada🇺🇸United States

Crypto Bonus200% up to $6000

Minimum deposit$20

Review Bet Now