MLS: San Diego vs. Portland Timbers Picks, Odds, and Preview (Oct 26)

The excitement of the MLS Playoffs gets underway this weekend, as the first-round clashes are set. Game One in the series between San Diego and the Portland Timbers is set for Oct 26, and you can find the odds and our picks here.

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Event Overview

• When: Sunday, October 26, 2025. 9:30 PM ET
• Where: Snapdragon Stadium, San Diego
• How to Watch: Apple TV

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San Diego vs. Portland Timbers Odds

Match Result	Odds
San Diego	-158
The Draw	+331
Portland Timbers	+385

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Head-to-Head Record

There is nothing to separate these teams based on previous meetings with San Diego and Portland winning a game a piece across the three fixtures. The latest meeting between the sides was staged in October, with San Diego landing a 4-0 win.

ALSO SEE: Xfinity 500 Picks, Odds, and Preview (Oct 26)

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Game Preview

The Western Conference playoffs get underway this weekend, and there will be a lot of pressure on San Diego FC to maintain their strong regular season form. San Diego finished top of the Western Conference standings, winning 19 of their 34 matches. They climbed to the summit of the table on the final day of the regular season after beating the Timbers.

That success means that San Diego have won each of their last two. That is a strong return to form after having gone three without a win in the MLS. However, it could be argued that their best form has come on the road this season, with 12 of their 19 wins being picked up on their travels.

Portland Timbers will continue their playoff journey this weekend, despite many believing that their journey would be over after losing each of their last two matches in the regular season.

However, they showed great character in the wild-card round to overcome Real Salt Lake. Felipe Mora scored twice in the win on Wednesday, but the Timbers were excellent value for the success after dominating the ball and looking efficient in the final third of the field.

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San Diego vs. Portland Timbers Picks

Despite San Diego’s indifferent home record, it is worth considering that the Timbers have struggled on the road, winning just four of their 17 games. Therefore, a home win still appears to be the most logical outcome when making San Diego vs. Portland Timbers picks.

Free Pick:

• San Diego (-158)