Champions League: Liverpool vs. Real Madrid Picks, Odds, and Preview (Nov 4)

Two previous winners of the UEFA Champions League lock horns in the League Phase on November 3. A thrilling night of action is set for Anfield, as Real Madrid visit Liverpool. You can find the odds and our picks for this clash of European heavyweights here.

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Event Overview

• When: Tuesday, November 4, 2025. 3:00 PM ET
• Where: Anfield, Liverpool, England
• How to Watch: CBS

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Liverpool vs. Real Madrid Odds

Match Result	Odds
Liverpool	+150
The Draw	+292
Real Madrid	+163

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Head-to-Head Record

Real Madrid have won seven of their last eleven competitive matches against Liverpool, with the Reds winning just three times over the same period. Liverpool landed a 2-0 win in the League Phase against Los Blancos last November.

ALSO SEE: Sao Paulo Grand Prix Picks, Odds, and Preview (Nov 9)

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Game Preview

A potentially season-defining week for Liverpool kicks off with a home showdown against Real Madrid on Tuesday. It has been a forgettable start to the campaign for the defending Premier League champions, and a recent win against Aston Villa does little to improve their confidence. The Reds have suffered defeats in six of their last eight competitive matches.

In fact, their win over Villa on Saturday was as much to do with their opponents’ inability to play out from the back, as defensive errors enabled Liverpool to score twice. The Reds will need to be more difficult to break down against Real Madrid this week, having allowed 14 goals across their last eight matches.

Real Madrid have enjoyed an excellent start to life under Xabi Alonso. Los Blancos currently sit five points clear at the top of the La Liga standings, having won an impressive ten of their opening eleven matches in 2025-26.

Their red-hot form continued last Saturday after blitzing Valencia to win by a four-goal margin. Kylian Mbappe scored twice in that success, while Jude Bellingham also netted after returning to the starting eleven following a lengthy injury absence.

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Liverpool vs. Real Madrid Picks

Real Madrid have a 100% record in the Champions League so far this season, and their prowess at both ends of the field could be challenging to dismiss this week. Despite a recent win, Liverpool’s performances have remained extremely poor, and they could suffer an embarrassing home loss at the hands of Los Blancos on Tuesday.

Free Pick:

• Real Madrid (+163)