Skip to content

Expert prediction

NCAA Second Round: TCU vs Duke Preview, Odds, Predictions (March 21)

  • Richard Pereira
  • Mar 21, 2026 at 12:04 PM EDT

Pick rationale

Analysis & key factors

  • The Horned Frogs got past Ohio State in the first round.
  • The Blue Devils rallied to beat Siena in the Round of 64.
  • This marks the first all-time matchup between the two squads.

The second round of the NCAA Tournament will progress as the ACC’s Duke Blue Devils take on the Big 12’s TCU Horned Frogs. The former stands out as the solid favorite, presenting the stakes that will be present in this tournament matchup.

How to Watch

  • When: Saturday, March 21, 5:15 pm ET
  • Where: Bon Secours Wellness Arena, Greenville, South Carolina
  • How to Watch: CBS

NCAA Matchup Odds & Lines

TeamOddsSpreadTotals
TCU-105+12O140
Duke-115-12U140

Game Preview

The Horned Frogs (23-11) experienced one of the closest matchups in the first round, avoiding a game-winning attempt from Ohio State to get to the second round. Micah Robinson scored a game-high 18 points on 4-of-6 shooting from 3-point range. David Punch recorded his fifth double-double of the season with 16 points and a career-high tying 13 rebounds.

The Blue Devils (32-2) suffered a slow start in a stunning first-half display against Siena. Despite this, they ignited a rally in the second half to dispatch the Saints in the last 20 minutes of regulation. Their defense held the Saints to 8-of-34 shooting (23.5 percent) in the second half and out-rebounded Siena 30-13 after intermission. Duke received a career-high 19 points from Cayden Boozer and Cameron Boozer’s 20th double-double of the season to help power the comeback. Isaiah Evans tallied his first career double-double with 16 points and 10 rebounds.

TCU vs Duke Head-to-Head

The two programs are facing each other for the first time in their respective histories.

TCU vs Duke Predictions

The winner of this matchup will go to the Sweet 16 as they face the victors between St. John’s and Kansas. TCU will have its hands full when it comes to keeping Cameron Boozer away from the hoop. This paves the way for Cayden Boozer and Isaiah Evans to play bigger roles in leading Duke past the Horned Frogs’ scrappiness. Our betting pick here is the Blue Devils to defend a 12-point spread.

NCAAB

More Predictions

NCAAB Insight

NFL Odds, Predictions: Broncos vs. Cardinals Week 7 Preview & Picks (Oct 25)

Cards beat the Rams on the road, which gave them a massive morale boost ahead of this event. Meanwhile, the Broncos are in excellent shape, with 4 wins in 5 weeks. Both teams aim for a triumph in Glendale, yet who will come out on top? Stay tuned with us to see the latest NFL […]

Nikola Velickovic 2 min read

NCAAB Insight

Men’s National Championship: UConn vs Michigan Preview, Odds, Predictions (April 6)

The NCAA Tournament has come down to its last game of the 2025-26 campaign, seeing the Big East’s UConn Huskies duke it out with the Big Ten’s Michigan Wolverines. The latter stands out as the slight favorite, presenting the high stakes that will be actively present in this championship showdown. How to Watch NCAA Matchup […]

Richard Pereira 2 min read

NCAAB Insight

NIT Championship: Tulsa vs Auburn Preview, Odds, Predictions (April 5)

The 2026 NIT will come to an end as the Auburn Tigers take on the Tulsa Golden Hurricane on Sunday night. The former stands out as the slight favorite, meaning that Tulsa will have its work cut out for them throughout the championship showdown. How to Watch NCAA Matchup Odds & Lines Team Odds Spread […]

Richard Pereira 2 min read

NCAAB Insight

College Basketball Crown Championship: Oklahoma vs West Virginia Preview, Odds, Predictions (April 5)

The 2026 College Basketball Crown will come to a close when the West Virginia Mountaineers take on the Oklahoma Sooners. The Sooners stand out as a slight favorite, paving the way for a great showdown in the championship round. How to Watch NCAA Matchup Odds & Lines Team Odds Spread Totals Oklahoma -115 -3 O137 […]

Richard Pereira 2 min read

NCAAB Insight

Women’s National Championship: South Carolina vs UCLA Preview, Odds, Predictions (April 5)

The championship game of the 2026 NCAA Women’s Tournament has arrived as it features a battle between the SEC’s South Carolina Gamecocks and the Big Ten’s UCLA Bruins. The former comes out as the slight favorite as both teams compete for the right to end the campaign as national champions. How to Watch NCAA Matchup […]

Richard Pereira 2 min read