Man City vs. Southampton FA Cup Picks – Betting Preview, Team News, Predictions, and Prop Pick (Apr 25) 

• When: Saturday, April 25, 2026. 12:30 PM ET
• Where: Wembley Stadium, London, England
• How to Watch: ESPN

Match Result	Odds
Man City	-450
The Draw	+645
Southampton	+1100

Man City vs. Southampton Preview

All eyes will be on Wembley Stadium this weekend, as the final in the oldest domestic cup competition will be set. The first of the FA Cup semi-finals will see Premier League-chasing Man City take on Championship promotion hopefuls Southampton.

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Man City Stats & Team News

• Overall Record: 21-7-5
• Home Record: 12-3-1
• Road Record: 9-4-4

Despite being written off by many this season, Man City are on course for a domestic treble in 2025-26. Pep Guardiola has guided City into the FA Cup final in each of the last three seasons, although they have lost two of their last three appearances in the showcase.

City’s record against lower league teams is impossible to overlook this weekend, as they have won each of their last 21. Over that period, they have scored 84 goals and have conceded just eleven. Erling Haaland was in inspired form in the previous round, netting a hat-trick in a 4-0 win over Liverpool.

Team News:

Rodri (Other), Ruben Dias (Muscle), Gosko Gvardiol (Leg)

Likely Line-Up:

(4-2-3-1): Trafford (GK); Nunes, Guehi, Ake, O’Reilly; Silva, Gonzalez; Semenyo, Cherki, Doku; Haaland

Southampton Stats & Team News

• Overall Record: 21-13-10
• Home Record: 12-7-3
• Road Record: 9-6-7

Tonda Eckert has done an excellent job at Southampton since arriving late last year. However, the Saints will be huge outsiders to upset the odds this weekend. But, that wouldn’t be a huge negative in their chances after beating Arsenal in the previous round.

Southampton face a crucial week in their season, with a must-win Championship clash against Ipswich Town taking place next week in their battle for promotion. The Saints have gone 20 without defeat, but they haven’t reached the FA Cup final since 2003. In fact, no non-EPL side has reached the final since Cardiff City in 2007-08.

Team News:

Mads Roerslev (Knee), Alex McCarthy (Wrist)

Likely Line-Up:

(4-2-3-1): Peretz (GK); Bree, Harwood-Bellis, Wood, Manning; Downes, Charles; Fellows, Azaz, Archer; Larin

Head-to-Head Trends

• Man City have won three of their four FA Cup ties against Southampton, which includes a 4-1 success in the 2021-22 season.
• Southampton have lost 13 of their previous 18 against City in all competitions. The latest meeting ended in a 0-0 draw in May 2025.

Man City vs. Southampton Prop Picks

Antoine Semenyo has been a key player throughout City’s run to the semi-finals, having registered four goal involvements in as many appearances. His directness will cause issues for the Saints on Saturday, having completed 3.20 dribbles per 90 and averaging 1.21 shots on target per appearance.

• Antoine Semenyo to Score vs. Southampton @ -110 with BetOnline

Man City vs. Southampton Picks

A win for Man City is incredibly hard to overlook this weekend, but Southampton’s 20-game unbeaten run could ensure that Guardiola’s side will need to work hard.

• Man City @ -450 with BetOnline