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Expert prediction

Serie A: Roma vs. Inter Milan Preview, Odds, Picks (Sep 19)

  • Nikola Velickovic
  • Sep 17, 2026 at 5:17 AM EDT

Pick rationale

Analysis & key factors

  • Roma vs. Inter Milan odds favor Inter as narrow away favorites at +155.
  • Roma sit atop Serie A, allowing just one goal.
  • Both teams have 4 wins in 4 Serie A fixtures.

The No. 1 spot is at stake, with both Roma and Inter at the top of the table and holding a perfect record after 4 rounds. This is the absolute derby of the round, so it needs a preview.

Here are more soccer picks.

How to Watch

  • When: Saturday, September 19, 12 PM ET
  • Where: Stadio Olimpico, Rome, Italy
  • How to Watch: Paramount+

How to Watch

Match ResultOdds
Roma+170
Tie+240
Inter Milan+155

Game Preview

Gianpiero Gasperini was always considered an offensive-minded genius. Now, he leads the best defense in Serie A, having allowed only one goal in 4 Serie A fixtures.

Offensively, Roma has Donyell Malen, who netted 6 goals in 4 appearances. The Dutch forward has been excellent since his arrival last winter, and is the focal point of Il Lupi’s attack. Of course, he has a huge help coming from Paulo Dybala, who posted 4 assists.

On the other hand, Inter has the best attack, netting 2.8 goals per game. Their defense is more vulnerable, having allowed 6 goals across four matches, but overall, Inter is confident and has no trouble winning games.

When it comes to the efficiency of their games, it’s pretty high – 4 of the last 5 saw over 2.5 goals and both teams netting. So, that’s something worth knowing when betting on Serie A or Inter.

Roma vs. Inter Head to Head

Inter won both games last year, 0-1 in Rome, and 5-1 at Meazza. The Nerazzurri have triumphed in their last 5 visits to Olimpico.

Roma vs. Inter Milan Predictions

Both teams to score is our pick here. Inter has too much firepower for Roma to contain it. On the other hand, Il Lupi is very good at home, while Nerazzurri have defensive problems no matter the venue. Therefore, BTTS is the best pick here.

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Soccer

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