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Expert prediction

No. 6 Iowa State vs No. 23 BYU Preview, Odds, Predictions (Feb. 21)

  • Richard Pereira
  • Feb 21, 2026 at 7:10 PM EST

Pick rationale

Analysis & key factors

  • The Cyclones are in the Big 12 regular-season title race.
  • The Cougars have lost four of their last six contests in league play.
  • This marks the 11th all-time matchup between the two Big 12 squads.

The Big 12 will cap off the final ranked matchup of the Feb. 21 slate as the No. 23 BYU Cougars host the No. 6 Iowa State Cyclones. The latter comes out as the slight favorite, giving U.S. fans being awake in the late hours a solid game to observe throughout the night.

How to Watch

  • When: Saturday, Feb. 21, 10:30 pm ET
  • Where: Marriott Center, Provo, Utah
  • How to Watch: ESPN

NCAA Matchup Odds & Lines

TeamOddsSpreadTotals
Iowa State-115-2.5O154
BYU-105+2.5U154

Game Preview

The No. 6 Cyclones (23-3, 10-3 Big 12) are coming off a huge victory, stunning the No. 2 Houston Cougars at home. They’ve won seven of their last eight games, making their way up the conference standings while being in the regular-season title race. Milan Momcilovic has been the nation’s best marksman this season as the junior leads the country in 3-point percentage, producing 18 points and 3.2 rebounds per game. Tamin Lipsey holds the most steals in program history and is in the top three in Big 12 history for career steals, averaging 13 points and 5.3 assists per contest this season.

The No. 23 Cougars (19-7, 7-6 Big 12) are in a brutal spot this season, seeing their star player Richie Saunders go down for the rest of the campaign. He tore his ACL last week, significantly damaging the hopes for BYU to make a deep postseason run. AJ Dybantsa will handle more duties as the star freshman made strides throughout the season. He has been averaging 24.8 points, 6.6 rebounds, 3.3 assists, and 1.2 steals per game throughout 26 appearances. On another note, Robert Wright III will look to be active in this game, producing 18.5 points, 4.8 assists and 3.7 rebounds per contest.

Iowa State vs BYU Head-to-Head

The two programs have had 10 meetings in their history, and the result is 7-3 for the Cyclones. The last matchup was on March 2025 when BYU won 96-92 at home.

Iowa State vs BYU Predictions

The Cougars have enough talent to hang with the Cyclones, especially if AJ Dybantsa delivers a strong performance throughout the Saturday night matchup. However, the absence of Richie Saunders will leave a noticeable hole in the rotation, paving the way for Iowa State to assert its presence throughout the contest. Our betting pick here is the Cyclones to cover a 2.5-point spread.

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