Expert prediction
NCAA Women’s Sweet 16: Duke vs LSU Preview, Odds, Predictions (March 27)
Pick rationale
Analysis & key factors
- The Blue Devils took down Baylor in the Round of 32.
- The Tigers torched Texas Tech in the second round.
- This marks the seventh all-time matchup between the two squads.
The first half of the Sweet 16 of the 2026 NCAA Tournament progresses throughout the March 27 slate as the Duke Blue Devils take on the LSU Tigers on Friday night. The latter comes out as the solid favorite, paving the way for a strong matchup to tip-off the first portion of the Sweet 16.
How to Watch
- When: Friday, March 27, 10 pm ET
- Where: Golden 1 Center, Sacramento, California
- How to Watch: ESPN
NCAA Matchup Odds & Lines
| Team | Odds | Spread | Totals |
|---|---|---|---|
| Duke | -105 | +9.5 | O145 |
| LSU | -115 | -9.5 | U145 |
Game Preview
The Blue Devils (26-8) are on a remarkable roll in March Madness, first blowing out Charleston and Baylor to reach the Sweet 16. In the latest win, Delaney Thomas led all scorers with 17 points, while Toby Fournier contributed 15 in just 22 minutes of action. Ashlon Jackson totaled 12, while Taina Mair posted an impressive all-around effort of nine points, seven rebounds, eight assists and four steals.
The Tigers (29-5) continue building their case as a national championship contender this tournament, torching Jacksonville and most recently Texas Tech in the opening two rounds. LSU’s dynamic duo of senior Flau’jae Johnson and Mikaylah Williams were the leaders for LSU in the 54-point victory. Johnson and Williams combined to score 48 points with 24 each. Johnson had four rebounds, three assists and two steals, while Williams tallied seven rebounds, four assists, and one steal. The guards combined to go 18-of-28 from the field, 4-of-9 from behind the arc and 8-of-9 at the charity stripe.
Texas vs Purdue Head-to-Head
The two programs have had six meetings in their history, and the result is 3-3 for both teams. The last matchup was in December 2025 when LSU won 93-77 on the road.
Duke vs LSU Predictions
The winner of this matchup will take on the victors between UCLA and Minnesota in the Elite Eight on March 29. Duke hopes to have the upper hand over LSU with Delaney Thomas leading the attack. However, the Tigers possess an explosive attack as Flau’jae Johnson and Mikaylah Williams look to deliver crucial performances. Our betting pick here is for the Tigers to defend a 9.5-point spread.
- Free NCAAB pick: LSU Tigers -9.5
NCAAB
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