Serie A Matchday 4 Predictions: Best Bets, Odds & Weekend Picks

The 2026–27 Italian Serie A campaign returns from the international break with Gameweek 4 (September 11–14, 2026). Following an intense opening three weeks, top contenders look to solidify their league standing. Highlights of the slate include AC Milan traveling to Rome to face S.S. Lazio, SSC Napoli hosting Bologna FC, and Inter Milan taking on Udinese at the San Siro.

Below is our complete breakdown of top betting angles, value picks, and key fixture previews for Serie A Matchday 4.

Matchday 4 Best Bets & Top Value Picks

• Best Moneyline: Inter Milan vs. Udinese
• Best Both Teams to Score (BTTS): Lazio vs. AC Milan
• Top Value Over/Under: Inter vs. Udinese Over 2.5 goals

Key Fixture Breakdown & Predictions

---

Lazio vs. AC Milan Prediction & Odds

Kickoff: Saturday, September 12 | Stadio Olimpico, Rome

Match Preview

Under Gennaro Gattuso, Lazio plays aggressive, rough football. You won’t see too much beauty when the Eagles show up, but for the moment, they are perfect with three wins so far. AC Milan has two wins and a draw, which came last weekend on the road in Turin against Juve. This will be arguably the closest of all the Serie A fixtures this weekend, and as such we bet that it ends without a winner.

• Best Bet: Tie

---

Inter Milan vs. Udinese Prediction & Odds

Kickoff: Monday, September 14 | Giuseppe Meazza, Milan

Match Preview

From what we saw in Madrid, Inter should have beaten Real Madrid by at least a two-goal margin. Nerazzurri missed so many chances, it’s hard to believe. Now they come home angry and motivated to bounce back after the failure at Bernabeu, and to say it right away, we really don’t think Udinese has any chance of saving its skin in Milan. If Chivu’s unit plays 60% as it did in Spain, we expect to see their routine triumph.

• Best Bet: Inter -1.5

---

Torino vs. Roma Prediction & Odds

Kickoff: Monday, September 14 | Olympic Stadium, Turin

Match Preview

Donyell Malen is the man to stop at the moment. Sure, he didn’t score last weekend, but this guy is incredible and has 5 goals on his tally already. So Torino’s fragile defense will have to endure a massive challenge this Monday night. Roma plays this fixture on Monday because of the Champions League event it had on Thursday night against Fenerbahce in Istanbul. That one ended 1-1, and it did take some energy out of the Romans. Even so, Il Lupo is a better team, and we really believe it will post a victory in Turin.

• Best Bet: Roma