Expert prediction
WWE Wrestlepalooza Picks, Odds & Preview (Sep 20)
Pick rationale
Analysis & key factors
The first event of a landmark deal between the WWE and ESPN will be staged this Saturday, as WWE Wrestlepalooza will be held in Indianapolis. A stacked card of matches will create engagement, with the night set to be headlined by the final showdown between John Cena and Brock Lesnar. You can find the odds and picks for the event here.
How To Watch
- When: Saturday, September 20, 2025, at 7:00 P.M. ET
- Where: Gainbridge Fieldhouse, Indiana
- How To Watch: ESPN
John Cena vs. Brock Lesnar Odds & Picks
For the final time, long-term rivals John Cena and Brock Lesnar will collide. Cena’s retirement tour appeared to have hit a speed bump after losing the Undisputed WWE Championship at SummerSlam, leading to Lesnar’s shocking return to the company after a two-year absence.
It should be a gripping final match between the stars, who came up through the OVW ranks together, but it is challenging to overlook Cena claiming the win ahead of his final three months in WWE.
Free Pick:
READ MORE: USA Today 301 Picks, Odds & Preview (Sep 21)
CM Punk & AJ Lee vs. Seth Rollins & Becky Lynch Odds & Picks
For the first time in over ten years, AJ Lee will compete in a WWE match. The former Women’s champion returned to the company on SmackDown a few weeks ago, coming to the aid of her husband, CM Punk, who was being attacked by Beck Lynch.
The mixed tag match adds a fresh dynamic to the Punk/Rollins rivalry, and there is huge excitement surrounding Lee’s return to the company. We expect Lee to get the pin, beating Intercontinental champion, Lynch, in the process.
Free Pick:
Iyo Sky vs. Stephanie Vaquer Odds & Picks
A new Women’s champion will be crowned at Wrestlepalooza on Saturday. Vaquer earned her opportunity after winning the Evolution Battle Royal. However, her clash with Naomi was cancelled after the former champion relinquished the belt after announcing her pregnancy.
Iyo Sky was deemed to be the rightful challenger, as she was never pinned in her rematch. We could see a screwy finish on Saturday, with Asuka costing Sky the title.
Free Pick:
Other WWE Wrestlepalooza Picks
| Match | Pick |
|---|---|
| Cody Rhodes vs. Drew McIntyre | Cody Rhodes |
| The Usos vs. Bron Breakker & Bronson Reed | Bron Breakker & Bronson Reed |
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