Expert prediction
NFL Odds, Predictions: 49ers vs. Falcons Week 7 Preview & Picks (Oct 25)
Pick rationale
Analysis & key factors
- 49ers vs. Falcons total is set at 50.5 points
- The Niners are the only team with all 6 wins so far.
- The Falcons are dominant on both offense and defense.
The Falcons may have a negative record, but they are a formidable bunch. Kyle Shanahan knows that, which is why his undefeated Niners head to Georgia with the highest possible sense of urgency.
Stay tuned with us to see the latest NFL Week 7 picks.
How to Watch
- When: Sunday, October 25, 2026, 1:00 PM ET
- Where: Mercedes-Benz Stadium, Atlanta, Georgia
- How to Watch: FOX
49ers vs. Falcons Odds
Game Preview
The Niners have the 3rd offense in the league, 29.5 points, and the 4th defense, with 18.3 points per game. This pretty much says everything about how they play. When we add that SF is 6-0, any debate about their current form is closed.
WR Mike Evans probably won’t play, but Brock Purdy has plenty of good targets downfield. Plus, Christian McCaffrey is always ready to use his versatility and hurt the rivals.
Falcons lost in Chicago, 31-23. They were back in the final quarter, yet the Bears didn’t allow them to flip the result. Overall, they opened the game poorly, allowing the rivals to get a huge advantage.
Atlanta’s run offense ranks 4th in the NFL with 149.5 yards per game, and its defense also ranks 4th, allowing 83.2 yards per game. Bijan Robinson is one of the best rushers in the NFL with 641 yards on the ground.
49ers vs. Falcons Predictions
The Bears easily solved the Falcons, but that game was in Chicago. This one is indoor, and that’s where Atlanta shows its power. We won’t bet on the winner here, but go with Over 50.5 points. Game conditions will be perfect, and both sides have one hell of an offensive potential.
- Free NFL expert picks: Over 50.5 points
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