Expert prediction
MLS Picks: Best Bets, Odds & Predictions For This Weekend (Oct 24-25)
Pick rationale
Analysis & key factors
The MLS regular season is nearing its finish line, meaning the pressure on teams to pick up points in the playoff hunt steps up a gear this weekend. Crucial matches are set for across the Eastern and Western Conferences, and you can find our MLS picks for every matchup here, as well as a best moneyline pick, a standout BTTS angle, and an over/under goals selection.
MLS Best Bets For This Weekend & Top Value Picks
- Best Pick: Nashville SC (vs. Montreal)
- Best Both Teams to Score (BTTS): LAFC vs. LA Galaxy
- Best Value Over/Under: Colorado Rapids vs. Vancouver Whitecaps (Over 2.5 Goals)
ALSO SEE: Breeders’ Cup Classic Picks, Odds, Leading Contenders, Betting Insights & Analysis
Key Fixture Breakdown & Predictions
Columbus Crew vs. Toronto FC Prediction & Odds
Kickoff: Saturday, October 24 | 2:30 PM ET | ScottsMiracle-Gro Field, OH
Match Preview
The Columbus Crew remains in the midst of the Eastern Conference playoff fight, but their attention will be divided this week due to their participation in the U.S. Open Cup Final. The Crew have been in excellent recent form in the MLS, winning back-to-back fixtures, and landing victories in four of their previous five.
However, Toronto FC are very much the team on the rise in the East, climbing up to tenth in the standings after going three without defeat, and losing just three of their last 13. Toronto have also avoided defeat in their previous three against the Crew, indicating value in the away win on Saturday.
- Best Bet: Toronto (+365)
Colorado Rapids vs. Vancouver Whitecaps Prediction & Odds
Kickoff: Saturday, October 24 | 9:30 PM ET | Dick’s Sporting Goods Park, OH
Match Preview
An eye-catching matchup in the Western Conference this weekend will see the Vancouver Whitecaps travel to the Colorado Rapids. The Caps sit four points clear at the top of the West, and their place in the postseason has already been assured.
The Rapids still have work to do to secure their participation in the playoffs, but they currently sit three points clear in the Wild Card spot. Colorado have been hard to beat in recent fixtures, playing out draws in their previous three. Meanwhile, the Caps have won just once in their last five. Notably, the Rapids have excelled at home, avoiding defeat in nine.
- Best Bet: The Draw (+283)
LAFC vs. LA Galaxy Prediction & Odds
Kickoff: Sunday, October 25 | 9:00 PM ET | BMO Stadium, CA
Match Preview
All eyes will be on El Trafico this weekend, as Californian rivals LAFC and LA Galaxy collide at BMO Stadium on Sunday. LAFC will secure a postseason berth with a win this weekend, but it is a notable concern that they have picked up victories in just two of the last 13 rounds.
In contrast, the Galaxy have stormed into the playoff spots following an excellent run of form after avoiding defeat in five of their previous six. However, the fact that the Galaxy have won just one of their last six on the road is a worry. Interestingly, LAFC have also avoided defeat in eleven of their 13 head-to-heads against the Galaxy at BMO Stadium.
- Best Bet: LAFC (-195)
MLS Best Parlay Pick This Weekend
- Best MLS Parlay Bet: Nashville SC, LAFC, and Houston Dynamo All To Win & Over 2.5 Goals in Colorado vs. Vancouver (+897)
Best MLS Picks For All Matches This Weekend
| Date | Kick-Off Time | Match | MLS Picks |
|---|---|---|---|
| Saturday, October 24 | 1:30 PM ET | CF Montreal vs. Nashville | Nashville SC |
| Saturday, October 24 | 3:30 PM ET | Columbus Crew vs. Toronto FC | Over 2.5 Goals |
| Saturday, October 24 | 5:30 PM ET | NY Red Bulls vs. Inter Miami | BTTS |
| Saturday, October 24 | 7:30 PM ET | Philadelphia Union vs. New England Revolution | Philadelphia Union |
| Saturday, October 24 | 7:30 PM ET | Atlanta United vs. Chicago Fire | Over 2.5 Goals |
| Saturday, October 24 | 7:30 PM ET | Orlando City vs. NYCFC | Orlando City |
| Saturday, October 24 | 7:30 PM ET | D.C. United vs. FC Cincinnati | FC Cincinnati |
| Saturday, October 24 | 8:30 PM ET | FC Dallas vs. San Jose Earthquakes | FC Dallas |
| Saturday, October 24 | 8:30 PM ET | Houston Dynamo vs. Minnesota United | Houston Dynamo |
| Saturday, October 24 | 8:30 PM ET | Sporting KC vs. Austin FC | Under 2.5 Goals |
| Saturday, October 24 | 9:30 PM ET | Colorado Rapids vs. Vancouver Whitecaps | Colorado Rapids and Draw |
| Saturday, October 24 | 9:30 PM ET | Real Salt Lake vs. St. Louis City | BTTS |
| Saturday, October 24 | 10:30 PM ET | San Diego FC vs. Seattle Sounders | Seattle Sounders |
| Saturday, October 24 | 10:30 PM ET | Portland Timbers vs. Charlotte FC | Over 2.5 Goals |
| Sunday, October 25 | 9:00 PM ET | LAFC vs. LA Galaxy | LAFC |
How to Bet On MLS This Weekend
These are the best sportsbooks for U.S. bettors to place wagers on the MLS today:
Sportsbook ratings
BetOnline
RegionsAustraliaCanadaUnited States
No Strings Welcome Offer50% up to $250
Minimum deposit$10 Crypto
BetUS
RegionsCanadaUnited States
Welcome Bonus125% up to $2500
Minimum deposit$100
Lucky Rebel
RegionsCanadaUnited States
Welcome Bonus125% Free + 50 Free Spins
Minimum deposit$50
Soccer
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